Brain scan study aims to personalize anxiety treatment

NCT ID NCT02220309

Completed Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Stanford study explores how brain circuits relate to anxiety and depression. 167 participants with recent symptoms (no diagnosis needed) undergo brain scans and cognitive tests. Some also receive a 12-week course of pramipexole medication or rTMS therapy. The goal is to understand which brain areas are involved and eventually personalize treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pramipexole
What this could lead to: If successful, this could help personalize treatments for anxiety and depression by linking specific brain circuits to better outcomes.
What could go wrong: This is an early-stage study focused on understanding brain function, not proving a treatment works. The medication and therapy may not help everyone and could have side effects.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder bipolar disorder Depression depressive disorder phobic disorder post-traumatic stress disorder social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DEPRESSION

Contacts and locations

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Locations

Gronowski Center-5150 El Camino Real

Los Altos, California, 94022, United States
Stanford University Department of Psychiatry

Stanford, California, 94305, United States
VAPAHCS/Palo Alto MIRECC-3801 Miranda Avenue

Palo Alto, California, 94304, United States

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