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Brain scan study aims to personalize anxiety treatment

NCT ID NCT02220309

Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Stanford study explores how brain circuits relate to anxiety and depression. 167 participants with recent symptoms (no diagnosis needed) undergo brain scans and cognitive tests. Some also receive a 12-week course of pramipexole medication or rTMS therapy. The goal is to understand which brain areas are involved and eventually personalize treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pramipexole
What this could lead to
If successful, this could help personalize treatments for anxiety and depression by linking specific brain circuits to better outcomes.
What could go wrong
This is an early-stage study focused on understanding brain function, not proving a treatment works. The medication and therapy may not help everyone and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

167 people

The number who actually took part.

Start date

Aug 2013

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

We expect to enroll 160 individuals spanning the spectrum of anxiety and associated mood symptoms. These individuals include patients of the Gronowski Center, a community clinical psychology center in Palo Alto. We will also recruit from the community through various advertisements. Further, participants will include healthy people recruited by advertisement.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Recent experiences of anxiety and/or depression * Ages 18-65 Exclusion Criteria: * Specific psychiatric medications (case-by-case basis) * A diagnosis of Bipolar 1 Disorder, Schizophrenia, or Obsessive Compulsive Disorder * Any of the following medical conditions: Parkinson's disease; liver or kidney disease; history of epilepsy or seizures; history of cardiovascular disorders (specifically orthostatic hypotension)

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder bipolar disorder Depression depressive disorder phobic disorder post-traumatic stress disorder social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Depression

Contacts and locations

Locations

  • Gronowski Center-5150 El Camino Real

    Los Altos, California, 94022, United States

  • Stanford University Department of Psychiatry

    Stanford, California, 94305, United States

  • VAPAHCS/Palo Alto MIRECC-3801 Miranda Avenue

    Palo Alto, California, 94304, United States

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