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Could an antidepressant boost psoriasis treatment?

NCT ID NCT07432815

Recruiting now Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
methotrexate and escitalopram
What this could lead to
If it works, this could point toward a better treatment approach for people with both psoriasis and depression or anxiety.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The combination therapy may not work better than methotrexate alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression depressive disorder psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DEPRESSION PSORIASIS

Contacts and locations

Locations

  • Kasralainy

    RECRUITING

    Cairo, Cairo Governorate, 11562, Egypt

    Contact Email: •••••@•••••

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