Could an antidepressant boost psoriasis treatment?
NCT ID NCT07432815
First seen Feb 28, 2026 · Last updated Jun 22, 2026 · Updated 13 times
Summary
This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination works better.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kasralainy
RECRUITINGCairo, Cairo Governorate, 11562, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methotrexate and escitalopram
What this could lead to
If it works, this could point toward a better treatment approach for people with both psoriasis and depression or anxiety.
What could go wrong
This is a small, early-phase trial with only 40 participants, so results may not apply to everyone. The combination therapy may not work better than methotrexate alone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.