PSORIASIS

This study follows 200 Italian adults with moderate-to-severe psoriasis who are already taking deucravacitinib. Researchers want to see how well the drug controls skin symptoms and improves quality of life in real-world settings, not just in a lab. The goal is to understand its l…

This study tests whether choosing biologic drugs based on individual patient profiles works better than standard selection for people with psoriasis or psoriatic arthritis. About 50 adults will be randomly assigned to either a personalized or standard treatment group and followed…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study compares two oral medications, methotrexate and tofacitinib, to see which is more effective at reducing psoriasis plaques. It involves 75 adults with moderate to severe chronic plaque psoriasis who have not responded well to topical treatments. The main goal is to meas…

This study compares the effectiveness and safety of different doses and schedules of guselkumab in 400 Chinese adults with moderate to severe plaque psoriasis. Participants will receive either a high dose, an extended-interval dose, or the standard dose. The goal is to find the b…

This study looks at how well and how safely a medicine called guselkumab works for people with moderate to severe psoriasis who have switched from another medicine, ustekinumab. About 200 adults will be followed for a year in regular doctor visits. The main goal is to see how man…

This study tests a new medication called picankibart (IBI112) in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. The goal is to see if it can clear or greatly improve skin patches compared to a placebo. About 104 participants will receive either the drug or a du…

This study tests whether early use of the drug bimekizumab can delay or prevent chronic inflammation in people with mild plaque psoriasis. 40 adults with recent-onset or long-standing mild psoriasis will receive either bimekizumab injections or a topical steroid cream. The goal i…

This study tests whether a friendly bacteria called Lactobacillus plantarum can help treat psoriasis by restoring the skin's natural balance. Researchers will give the probiotic or a placebo to 184 adults with mild-to-moderate psoriasis and measure changes in skin moisture, appea…

This study looks at whether people with psoriasis who are doing very well on the drug guselkumab (Tremfya) can safely wait longer than the usual 8 weeks between injections. Researchers will follow 100 adults whose doctors have already extended their dosing interval to more than 9…

This early-stage trial tests whether a new biosimilar drug called CKD-704 works like the approved psoriasis treatment Skyrizi. About 213 healthy adults will receive a single dose of either CKD-704, EU-approved Skyrizi, or US-licensed Skyrizi. Researchers will compare how the drug…

This study looks at whether eating a Mediterranean diet can improve psoriasis symptoms in people who are about to start a biologic medication (anti-IL-17 or anti-IL-23). About 36 adults with moderate to severe psoriasis will be randomly assigned to follow the diet or not. The goa…

This study follows 350 adults in France with moderate-to-severe plaque psoriasis who are starting a new medication called deucravacitinib. Researchers will observe how well the drug works in real-world conditions, including its effect on skin clearance and quality of life. The go…

This study is for adults with moderate-to-severe plaque psoriasis who are also overweight or obese. Researchers want to see if adding the weight-loss drug tirzepatide to the standard psoriasis treatment ixekizumab improves skin clearance and helps people lose at least 10% of thei…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. 176 adults with psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the drug can stop art…

This study looks at whether adding treadmill walking to a calorie-restricted diet can improve psoriasis severity and body measurements in women who have both psoriasis and polycystic ovary syndrome (PCOS). About 40 obese women with these conditions will take part. Researchers wil…

This study tests a new skin barrier cream against plain petrolatum (like Vaseline) in 26 adults with mild skin conditions like eczema, psoriasis, or dry skin. Participants apply the cream twice daily for 28 days to see if it improves hydration, redness, and itch better than petro…

This study is testing a new laser called PALLAS to treat skin diseases like vitiligo, psoriasis, alopecia areata, and atopic dermatitis. About 50 people will receive UVB laser treatments twice a week for up to 3 months. The goal is to see if the laser improves the skin condition …

This study tests whether a daily magnolia supplement (Viv) can lower immune markers in the blood of adults with psoriasis. 100 participants will take either Viv or a placebo for 3 months and provide blood samples at home. Researchers will measure changes in inflammatory proteins …

This study looks at whether avoiding wheat can reduce skin inflammation and stomach discomfort in people with mild-to-moderate psoriasis. About 82 adults will follow either a wheat-free diet or a regular diet for several weeks. Researchers will track changes in skin severity, gut…

This study tests whether a type of talk therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help people with psoriasis feel less stressed, anxious, or depressed. The therapy combines mindfulness and cognitive techniques to improve self-compassion and a sense of control …

This study looks at 40 adults with moderate-to-severe psoriasis who also have depression or anxiety. Half will get methotrexate alone, the other half methotrexate plus an antidepressant (escitalopram). Over 6 months, researchers will track skin improvement and mental health chang…

This study follows 2500 adults with moderate-to-severe plaque psoriasis who are starting a new advanced therapy. Researchers will check their skin at 2, 4, and 16 weeks to see how quickly the treatment works. The goal is to collect real-world data, not to test a new drug.

This study aims to find gene patterns that can predict how well a person with psoriasis will respond to certain FDA-approved drugs. About 56 participants will try two different psoriasis medications for 8 weeks each, while researchers take blood and skin samples. The goal is to m…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at immune system signals in the blood and skin of people with psoriasis, comparing those who also have joint pain (psoriatic arthritis) to those who don't. Researchers want to find out what makes some people develop joint problems. The study involves 40 adults an…

This study looks at whether biologic drugs for psoriasis (like anti-TNF, anti-IL-17, and anti-IL-23) increase the chance of getting or having a return of genital warts. These drugs can change the immune system's ability to fight HPV, the virus that causes warts. Researchers will …

This study aims to find biological markers in the skin and blood that can predict how well people with chronic inflammatory skin diseases (like psoriasis, eczema, and lupus) will respond to treatments. Researchers will follow 830 adults over one year to see which markers are link…

This study looks at how the body processes Hemay005 tablets in people with mild or moderate liver problems compared to those with normal liver function. The goal is to find the right dose for patients with liver issues. 24 adults with psoriasis will take a single dose and have th…

This study looks at people with psoriasis who have already tried several different biologic drugs. Researchers will use information from past clinic visits to see if each new treatment works as well as the first. The goal is to understand how well people respond when they need th…

This study aims to understand which genes are active in the skin inflammation of psoriasis. Researchers will measure specific inflammatory markers in 13 adults with psoriasis. The goal is to find better ways to track and manage the disease in the future.

This study aims to test an educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and are considering treatment with immune checkpoint inhibitors. Researchers will ask about 125 patients and their doct…

This study will follow 1,000 adults with psoriasis to understand how the skin condition is linked to heart disease. Researchers will use heart tests and blood markers to find early signs of heart problems. The goal is to improve heart health monitoring for people with psoriasis.

This study tests whether a 6-week balanced diet can lower inflammation in people with psoriasis. Using a new, more sensitive PET scanner, researchers will measure inflammation in the skin, joints, and blood vessels before and after the diet change. Only 5 adults with psoriasis wh…

This study aims to understand how the immune system and skin healing are connected in people with primary immunodeficiency, psoriasis, or eczema, as well as in healthy volunteers. Researchers will collect skin biopsies, blood samples, and optional skin swabs to analyze microbes a…