PSORIASIS

This study follows 200 Italian adults with moderate to severe psoriasis who are already taking deucravacitinib. Researchers will track how well the drug controls symptoms, its side effects, and how it affects quality of life over time. The goal is to see how the treatment works i…

This study watches 200 adults with moderate to severe psoriasis who switch from the drug ustekinumab to guselkumab. Researchers want to see if the new drug safely controls skin plaques better. Participants continue their normal care, and the study tracks their progress for up to …

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study looks at whether people with psoriasis who are doing very well on guselkumab (Tremfya) can safely wait longer than the usual 8 weeks between injections. Researchers will follow 100 adults whose doctors have already extended their dosing interval to more than 9 weeks. T…

This study tests a new biosimilar drug called CKD-704 against the approved psoriasis treatment Skyrizi. Healthy adults aged 18 to 55 will receive a single dose of one of the three versions to compare how the drug moves through the body, its safety, and any immune reactions. The g…

This study looks at whether adding tirzepatide (a weight-loss medication) to ixekizumab (a psoriasis treatment) helps adults with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 participants will receive both drugs for up to 12 months. The main goa…

This study tests a new drug called picankibart in teenagers aged 12 to 18 with moderate to severe plaque psoriasis. The goal is to see if it safely reduces skin plaques by at least 75% compared to a placebo. About 104 participants will receive either the drug or a placebo, and re…

This study compares two oral medications, methotrexate and tofacitinib, to see which works better for chronic plaque psoriasis. About 75 adults with moderate-to-severe psoriasis will take one of the drugs for 12 weeks. The main goal is to measure how many people achieve at least …

This study tests whether the drug bimekizumab, given early in plaque psoriasis, can delay or prevent the disease from becoming a long-term condition. 40 adults with mild psoriasis (less than 6 months or more than 2 years) will receive either bimekizumab injections or a topical st…

This study compares three ways of giving guselkumab to Chinese adults with moderate to severe plaque psoriasis: a high dose, an extended interval between doses, and the standard dose. The goal is to see which approach works best and is safest over 86 weeks. About 400 participants…

This study compares two ways of choosing biologic drugs for people with psoriasis or psoriatic arthritis: one uses a pre-screen strategy, the other follows standard guidelines. About 50 adults aged 18-75 are participating across multiple hospitals in Taiwan. Researchers will trac…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. About 176 adults with psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the drug reduce…

This study compares two treatments for people who have both psoriasis and depression or anxiety. One group gets methotrexate alone, the other gets methotrexate plus an antidepressant (escitalopram). Over 6 months, researchers will measure changes in skin severity, quality of life…

This study looks at whether removing wheat from the diet can reduce skin inflammation and stomach discomfort in people with mild-to-moderate psoriasis. About 82 adults will follow either a wheat-free diet or a regular diet for several weeks, and then some will try eating wheat ag…

This study tests a medicated foam called ARQ-154 in 16 children aged 2 to 12 with psoriasis on their scalp and body. The goal is to see how much of the drug enters the blood and if it is safe. Participants apply the foam daily for several weeks, and doctors monitor side effects a…

This study tests whether a probiotic called Lactobacillus plantarum can help ease psoriasis symptoms. Researchers believe an imbalance in skin bacteria may play a role in the disease. About 184 adults with mild-to-moderate psoriasis will receive either the probiotic or a placebo …

This study tests whether a new skin barrier cream improves hydration, redness, and itch better than plain petrolatum in adults with mild psoriasis, eczema, contact dermatitis, or dry skin. 26 participants will apply the assigned cream twice daily for 28 days and attend weekly che…

This study tests whether an over-the-counter magnolia supplement called Viv can lower signs of immune activity in the blood of adults with psoriasis. One hundred participants will take either Viv or a placebo daily for three months and collect blood samples at home. Researchers w…

This study looks at whether adding treadmill walking to a restricted diet can improve psoriasis and polycystic ovary syndrome (PCOS) in women. Forty obese women with both conditions will be assigned to diet alone or diet plus walking. Researchers will measure changes in psoriasis…

This study is testing a new laser (PALLAS) to treat skin diseases like vitiligo, psoriasis, alopecia areata, and atopic dermatitis. About 50 adults will receive UVB laser treatments twice a week for up to 3 months. The goal is to see if the laser improves the skin condition and i…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and may receive immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to use and helpful for …

This study tests whether a 6-week balanced diet can lower inflammation in people with psoriasis. Five adults with psoriasis who eat a typical Western diet will get a total-body PET scan before and after the diet change. The goal is to see if the new EXPLORER PET scanner can detec…

This study looks at how well people with psoriasis respond when they need three or more biologic treatments in a row. Researchers will use existing medical records from NHS hospitals in England to track responses from the 1st to the 10th biologic. The goal is to understand if peo…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study aims to find gene markers that can predict how well a person with psoriasis will respond to certain drugs, so doctors can choose the right treatment from the start. About 56 adults with plaque psoriasis will try two FDA-approved drugs for 8 weeks each. Researchers will…

This study aims to understand which inflammatory genes are active in psoriasis, a chronic skin condition. Researchers will measure specific genes from skin samples of 13 adults with psoriasis. The goal is to find better ways to track and manage the disease, not to test a new trea…

This study is collecting health information from up to 10,000 people with conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to better understand these illnesses and help…

This study aims to understand how the immune system and skin healing are connected. Researchers will study people with primary immune deficiency, eczema, or psoriasis, as well as healthy volunteers. Participants will provide blood and skin samples to help identify differences in …

This study looks at whether biologic drugs for psoriasis (targeting TNF-α, IL-17, and IL-23) increase the risk of developing or having a return of genital warts. Researchers will review past medical records and follow 600 adults with moderate-to-severe psoriasis for 24 months. Th…

This early-stage study aims to understand how a potential psoriasis medication, called Hemay005, is processed by the body in people with different levels of liver function. It will enroll 24 adults, some with mild or moderate liver impairment and others with normal liver function…