PSORIASIS

This study looks at whether a daily pill called deucravacitinib can help people who have both moderate to severe psoriasis and eczema. About 50 adults will take the drug for 16 weeks while doctors track skin improvements and side effects. The goal is to find a treatment that work…

This study tests a new cream called HSK44459 in healthy volunteers and people with plaque psoriasis. The first part checks safety and how the body processes the cream. The second part looks at whether different strengths of the cream can improve psoriasis symptoms over 8 weeks. A…

This study tests a drug called guselkumab in children aged 6 to 17 with chronic plaque psoriasis. The goal is to see if it safely clears skin patches better than a placebo or another treatment. About 120 participants will receive injections and be monitored for 16 weeks.

This study follows 135 children aged 6 to 17 with moderate to severe plaque psoriasis who are already starting or have recently started treatment with ustekinumab (Stelara). Researchers are monitoring for serious side effects like infections, cancer, and autoimmune issues, as wel…

This Phase 1 study compares a new biosimilar drug, CMAB015, to the approved psoriasis treatment Cosentyx (secukinumab). The trial involves 114 healthy Chinese men who receive a single injection. Researchers will measure how the drug moves through the body, its safety, and whether…

This study looks at the long-term safety and effectiveness of the drug ESK-001 for people with moderate to severe plaque psoriasis. Participants are adults who have already completed a prior ESK-001 study. They will take ESK-001 twice daily for 24 weeks, and some may later switch…

This study is observing about 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who are taking Remsima (a biologic drug) either as a shot under the skin or through an IV. The goal is to track any serious side effects over time. Resear…

This study follows 250 adults in Greece who were recently diagnosed with moderate plaque psoriasis and are starting risankizumab, a drug that calms the overactive immune system. Researchers will measure how much the skin clears up and how quality of life improves over two years. …

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study follows people with moderate-to-severe plaque psoriasis who have already taken deucravacitinib in earlier trials. It aims to check the drug's long-term safety and how well it controls psoriasis over time. A smaller group will also test how the drug affects immune respo…

This study tests a single dose of brodalumab in children aged 6 to 17 with severe plaque psoriasis. The goal is to see how safe the drug is and how the body processes it. Only 2 children are enrolled, making this a very early look at the drug's effects in younger patients.

This study is tracking 3500 adults with moderate-to-severe psoriasis to compare the long-term safety of brodalumab with other psoriasis treatments. Researchers are specifically looking at rates of cancer (excluding skin cancer) in people taking brodalumab versus those on other bi…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This pilot study explores whether a 7-day fast followed by 11 weeks of a plant-based diet can reduce skin and joint symptoms in people with psoriasis and psoriatic arthritis. Researchers will also look at changes in gut bacteria and overall quality of life. The study involves 30 …

This study tests whether a daily pill called IRX4204 can safely improve mild to moderate plaque psoriasis in adults. Twenty participants will take the drug or a placebo for 28 days and have weekly checkups. The goal is to see if the drug clears or nearly clears skin plaques and i…

This early study will test a special microbubble bath system (Thera-Clean) on 20 people with certain skin diseases like epidermolysis bullosa, ichthyosis, atopic dermatitis, or psoriasis. The goal is to see if the chemical-free bubbles can clean wounds, reduce itching, and improv…

This study tests whether a TENS (transcutaneous electrical nerve stimulation) device can reduce the pain of biologic injections in people with psoriasis. About 20 adults will receive their injection in one thigh without TENS and in the other thigh with TENS pads placed nearby. Th…

This Canadian study follows about 394 adults with plaque psoriasis who are starting brodalumab as part of their regular care. Over 12 months, researchers measure changes in skin-related quality of life, work productivity, and treatment satisfaction. The goal is to understand how …

This study aims to understand inflammation in four chronic skin conditions: vitiligo, psoriasis, eczema (atopic dermatitis), and alopecia areata. Researchers will collect blood and small skin samples from 450 adults to analyze immune cells called T-cells. The goal is to describe …

This study is a large registry that follows nearly 16,000 people with psoriasis to monitor the long-term safety of several treatments, including biologic drugs like infliximab and ustekinumab. Participants receive their usual care while researchers track side effects, disease act…

This study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…

This study looks at medical records from over 1,200 psoriasis patients to find who is most likely to develop insulin resistance, a condition that can lead to diabetes. Researchers will use machine learning to build a simple tool that helps doctors estimate this risk. No new treat…

This study looks at whether weekly text reminders help people with psoriasis take their deucravacitinib medication as prescribed. Forty patients will be split into two groups: one gets reminders, the other does not. Researchers will interview participants to understand what helps…

This study follows 15,000 adults and children with skin conditions like eczema, psoriasis, and vitiligo to see how well current and new treatments work in real doctor visits. It does not test a new drug but instead collects information to help doctors understand which treatments …

This early-stage study is testing a single dose of an experimental drug called SHR-1139 in 24 healthy adults. The main goal is to see how safe the drug is and how the body processes it, not to treat any disease. Participants are healthy men and women aged 18 to 55. The results wi…

This study aimed to understand why psoriasis and lichen planus often appear on skin that is rubbed or irritated, like from tight clothing. Researchers planned to irritate a small patch of skin in people with these conditions and healthy volunteers, then take skin samples to study…

This registry is following 10,000 adults with psoriasis treated by dermatologists across North America. Researchers are collecting data on side effects, disease severity, and overall health to compare the safety of approved treatments, including newer biologic drugs. The goal is …

This study looks at how the drug tildrakizumab affects immune cells in the skin of 3 adults with moderate to severe plaque psoriasis. Researchers take small skin samples before and after treatment to see changes in certain cell types. The goal is to learn why the drug works well …

This study looks at whether the shingles vaccine (HZ/su) is safe for pregnant women aged 18-49 with weakened immune systems. Researchers will track about 2,800 women to see if the vaccine raises the risk of birth defects or other problems in their babies. The goal is to provide r…

This study looks at whether combining a medicated foam (Enstilar) with ultraviolet light therapy can change immune cells in psoriasis skin that may 'remember' the disease and cause it to return. Researchers will take skin samples from 12 adults with stable plaque psoriasis before…