PSORIASIS

This study is observing adults in Canada who are starting the psoriasis medication brodalumab as part of their regular care. Researchers will follow about 500 participants for one year to see how the treatment affects their quality of life, work productivity, and daily activities…

This study follows people with moderate-to-severe plaque psoriasis who continue taking the drug deucravacitinib long-term to monitor its ongoing safety and effectiveness. It also includes a smaller group to see if the drug affects how well vaccines for pneumonia and tetanus work.…

This study tested a daily pill called IRX4204 to see if it could safely improve skin symptoms in adults with mild to moderate plaque psoriasis. For 28 days, participants took either the drug or a placebo (inactive pill), and researchers compared their skin clearance and quality o…

This study is checking if a medication called ESK-001 is safe and keeps working for people with moderate-to-severe plaque psoriasis over a long period. It involves 1,680 adults who have already taken ESK-001 in a previous study. The research will see if the drug's benefits last a…

This study is testing if using two drugs together works better than one for adults who have both moderate-to-severe plaque psoriasis and are overweight or have obesity. About 250 participants will receive the psoriasis drug ixekizumab alone or combined with the weight-loss drug t…

This study aims to understand the long-term safety of the psoriasis medication brodalumab compared to other treatments. It will follow 3,500 adults with moderate-to-severe psoriasis who are already starting a new treatment as part of their regular care. The main goal is to track …

This study is checking the safety and how a single dose of the drug brodalumab moves through the body in children and teenagers with severe plaque psoriasis. It involves a very small group of participants, aged 6 to under 18. The main goal is to gather initial information on how …

This study is testing if a new drug called CMAB015 works as well as an already-approved drug, secukinumab, for treating moderate to severe plaque psoriasis. About 336 adults will receive injections of one of the two drugs for a year to see which is better at clearing skin and is …

This study is testing a drug called guselkumab to see if it can safely and effectively clear skin and improve quality of life for children and teenagers (ages 6 to 17) with moderate-to-severe plaque psoriasis. It's a large, late-stage trial comparing the drug against a placebo an…

This study is observing how well the already-approved medication risankizumab works for people in Greece who were recently diagnosed with moderate plaque psoriasis. It will follow 250 patients for about two years in their normal doctor's offices and clinics to see how the drug co…

This study is monitoring the long-term safety of the psoriasis medication ustekinumab in children and teenagers aged 6 to 17. Researchers are watching for potential side effects related to the immune system, such as serious infections or autoimmune reactions. They are also tracki…

This early study is testing a special bubble bath treatment called Thera-Clean for people with skin conditions like eczema, psoriasis, and epidermolysis bullosa. The treatment uses tiny bubbles to clean skin and wounds without chemicals, aiming to reduce itching, pain, odor, and …

This study is testing if a small, non-drug device called TENS can reduce the pain people feel when they inject their psoriasis medication. About 20 adults with psoriasis will try getting one injection with the TENS device on and one without, then report their pain levels. The goa…

This small pilot study is testing whether a smartphone app that delivers therapy, with some coach support, is a helpful and practical way for adults with psoriasis to manage co-occurring depression symptoms. All 30 participants will try the 8-week program. The main goals are to s…

This study aims to understand if a 'disease memory' remains in skin that appears healed from psoriasis. Researchers will treat 12 adults with a topical foam and light therapy, then take small skin samples to see how specific immune cells change. The goal is to learn more about wh…

This is an early safety study to see how the body handles a single dose of an experimental drug called SHR-1139. It involves 24 healthy volunteers and will check for side effects and measure how long the drug stays in the body. The goal is to gather basic safety information befor…

This study aims to understand how a specific psoriasis drug, tildrakizumab, works in the skin. Researchers will analyze tiny skin samples from three adults with moderate-to-severe psoriasis before and after treatment. The goal is to see how the drug changes skin cells over time t…

This study aims to create a tool that helps doctors predict which people with psoriasis are more likely to develop insulin resistance, a silent condition that raises the risk of diabetes and heart disease. Researchers will use existing medical records from over 1,200 patients to …

This study aimed to understand why minor skin irritation, like from tight clothing, can trigger psoriasis or lichen planus flare-ups, a reaction known as the Koebner phenomenon. Researchers planned to gently irritate a small area of skin on participants and then take tiny samples…

This study aims to understand why people with moderate-to-severe psoriasis sometimes don't take their oral medication as prescribed. Researchers will interview 40 patients to learn what helps some people stick to their treatment plan and what makes it hard for others. They will a…

This study aims to understand why a single dose of the psoriasis drug risankizumab (Skyrizi) can lead to long-term skin clearance for some people, even after stopping treatment. Researchers will analyze skin samples from 20 adults with moderate-to-severe psoriasis to see how the …

This study is collecting information about how safe and effective psoriasis treatments are in real-world settings. Researchers will follow 10,000 adults with psoriasis for at least 8 years to track side effects and how well different medications work. The goal is to better unders…

This large registry study follows over 15,000 people with psoriasis who are receiving various treatments, including biologic drugs like infliximab, ustekinumab, and guselkumab. The main goal is to monitor the long-term safety and side effects of these medications in real-world se…