Psoriasis patients see Real-World quality of life gains with brodalumab
NCT ID NCT05132231
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Canadian study follows about 394 adults with plaque psoriasis who are starting brodalumab as part of their regular care. Over 12 months, researchers measure changes in skin-related quality of life, work productivity, and treatment satisfaction. The goal is to understand how this medication helps people manage symptoms and improve daily functioning in real-world settings.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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394 people
The number who actually took part.
- Started
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Oct 2021
- Expected to finish
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Mar 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants initiating brodalumab as part of routine clinical care and who meet all of the inclusion and none of the exclusion criteria are eligible to participate in the study.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged ≥ 18 years old at the time of verbal consent to participate in the study. 2. Initiating brodalumab as part of routine clinical care through the SILIQ (brodalumab) Patient Support Program (PSP) for the treatment of plaque psoriasis but has not yet received their first dose. Decision to treat with brodalumab must have been reached prior to and independently of recruitment in the study. 3. Must be able to read, understand, and communicate in English or French. 4. Willing and able to provide informed consent on an online platform using an Independent Ethics Committee (IEC) or Institutional Review Board (IRB) approved electronic Informed Consent Form (ICF) in English or French. Exclusion Criteria: 1. Not willing or able to complete ePROs (electronic Patient Reported Outcomes) on an online platform (using a computer or mobile device). 2. Participation in brodalumab phase IV study (NCT04149587). 3. Participation in an interventional clinical trial concurrently or within the last 30 days prior to providing verbal consent to participate in this study. 4. Patient with Crohn's disease or with clinically significant hypersensitivity to brodalumab or to any of the excipients or component of the container (contraindications as per the Product Monograph). 5. Presence of any other serious and/or uncontrolled medical condition that, in the opinion of the investigator, prohibits the patient from participating in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CARE Site 03
Saskatoon, Saskatchewan, S7T 0G3, Canada
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CARE Site 04
Montreal, Quebec, H2E 1V4, Canada
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CARE Site 05
Barrie, Ontario, L4M 7G1, Canada
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CARE Site 06
Greater Sudbury, Ontario, P3C 1XB, Canada
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CARE Site 07
Laval, Quebec, H7N 6L2, Canada
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CARE Site 09
London, Ontario, N6H 5L6, Canada
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CARE Site 11
Ajax, Ontario, L1S 7K8, Canada
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CARE Site 12
Winnipeg, Manitoba, R3M 3Z4, Canada
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CARE Site 13
Richmond Hill, Ontario, L4C 9M7, Canada
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CARE Site 14
Hamilton, Ontario, L8N 1Y2, Canada
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CARE Site 15
Calgary, Alberta, T5J 3S9, Canada
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CARE Site 16
Toronto, Ontario, M5A 3R6, Canada
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CARE Site 17
Québec, Quebec, G3K 2P8, Canada
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CARE Site 18
Edmonton, Alberta, T5J 3S9, Canada
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CARE Site 20
Guelph, Ontario, N1L 0B7, Canada
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CARE Site 21
Edmonton, Alberta, T6W 0J5, Canada
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CARE Site 22
London, Ontario, N6A 5R9, Canada
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CARE Site 23
London, Ontario, N6A 2C2, Canada
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CARE Site 24
Hamilton, Ontario, L9B 1K5, Canada
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CARE Site 26
Calgary, Alberta, T2W 4X9, Canada
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CARE Site 27
Oshawa, Ontario, L1H 1B9, Canada
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CARE Site 28
Sherwood Park, Alberta, T8H 0P1, Canada
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CARE Site 30
Québec, Quebec, G1W 4R4, Canada
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CARE Site 31
Vancouver, British Columbia, V5Z 1M9, Canada
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CARE Site 32
Whitby, Ontario, L1N 8M7, Canada
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CARE Site 33
Markham, Ontario, L3P 1X3, Canada
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CARE Site 35
Saint Johns, Newfoundland and Labrador, A1E 1V4, Canada
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CARE Site 36
Winnipeg, Manitoba, R3C 0N2, Canada
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CARE Site 37
Edmonton, Alberta, T6X 0N9, Canada
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CARE Site 38
Drummondville, Quebec, J2B 5L4, Canada
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CARE Site 39
Saint-Jérôme, Quebec, J7Z 7E2, Canada
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CARE Site 40
Westmount, Quebec, H3Z 2S6, Canada
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CARE Site 41
Edmonton, Alberta, T6G 1C3, Canada
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CARE Site 42
Calgary, Alberta, T2J 7E1, Canada
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CARE Site 44
Mississauga, Ontario, L4W 0C2, Canada
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CARE Site 46
Québec, Quebec, G1V T3, Canada
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CARE Site 47
Sherbrooke, Quebec, J1L 0H8, Canada
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CARE Site 48
North York, Ontario, M3B 0A7, Canada
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CARE Site 49
Toronto, Ontario, M2N 3A6, Canada
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CARE Site 50
Laval, Quebec, H7P K7, Canada
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CARE Site 51
Niagara Falls, Ontario, L2E 6A6, Canada
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CARE Site 52
Saint-Charles-Borromée, Quebec, J6E 4P6, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Pilot study to evaluate the effect of nicotinamide riboside on immune activation in psoriasis
- Can monthly selfies and symptom logs reveal how chronic skin diseases flare and settle?
- Can we predict the path of chronic skin disease?
- Can a new pill tame psoriasis? early safety trial begins
- Can one pill tame four autoimmune diseases? a Long-Term trial puts it to the test
- Can a new skin ointment quiet psoriasis inflammation?