PSORIASIS

This phase 2 study tests whether a new drug called RAP-103, taken as a pill once or twice daily for 8 weeks, can improve skin symptoms and quality of life in 90 adults aged 18-70 with moderate-to-severe psoriasis. Participants are randomly assigned to receive one of two doses of …

This study tests an experimental drug called D-2570 in 75 adults with moderate to severe plaque psoriasis. Participants will receive either the drug or a placebo to see if it safely improves skin symptoms. The main goal is to measure at least a 90% reduction in psoriasis severity…

This study follows 200 adults with moderate-to-severe plaque psoriasis who have never taken biologic drugs before. Researchers will track how long participants continue taking guselkumab over two years and measure how well their skin clears up. The goal is to understand real-worl…

This study tests a pill called apremilast in 425 adults with moderate-to-severe psoriasis that has lasted at least 6 months. The goal is to see if it improves skin symptoms like redness and scaling over 32 weeks. Participants take the medication and are monitored for safety and e…

This study tests whether adding metformin (a diabetes drug) to secukinumab (a standard psoriasis medication) works better than secukinumab alone for treating moderate-to-severe plaque psoriasis in overweight or obese Chinese adults. About 186 participants will receive either the …

This study tests an experimental oral medication called HSK44459 for adults with moderate to severe plaque psoriasis. About 150 participants will receive either the drug or a placebo to see if it can reduce skin symptoms by at least 75% after 16 weeks. The goal is to control the …

This study compares two oral medications, methotrexate and apremilast, to see which one better reduces itching and improves quality of life in people with psoriasis. Eighty adults with psoriasis covering more than 8% of their body and related itching will take one of the two drug…

This study tests a new cream containing apremilast nanoparticles for treating mild to moderate plaque psoriasis. About 36 adults will use either the new cream, a standard steroid cream, or both for 12 weeks. The goal is to see if the new cream reduces psoriasis symptoms with fewe…

This study looks at whether losing weight can make standard psoriasis treatments more effective for overweight or obese patients with moderate-to-severe plaque psoriasis. About 70 participants will either receive standard care alone or standard care plus a personalized weight los…

This study looks at why people with psoriasis may be more likely to have gum disease. Researchers will measure stress and immune markers in saliva and gum fluid from 60 adults with psoriasis. The goal is to understand the biological connection, not to test a treatment. Participan…

This study tests a grain-of-rice-sized microdevice that places tiny amounts of approved drugs directly into patches of psoriasis or eczema. The goal is to see if the device can safely predict how a person's skin will respond to standard treatments. Ten adults with these skin cond…

This study tests whether high-resolution eye images, analyzed by artificial intelligence, can help predict and classify inflammatory skin diseases like psoriasis and eczema. Researchers will enroll about 950 people, including patients and healthy volunteers, to build a model that…

This study will look at existing medical records from 20,000 people aged 12 and older in Italy who have psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to learn about the types of treatments patients receive, how their diseas…

This study looks at whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults with psoriasis will be split into three groups: one gets weekly AI videos, another gets weekly video calls with a …

This study will follow 50 people in Costa Rica who are already taking IL-23 inhibitors (guselkumab or risankizumab) for psoriasis or psoriatic arthritis. Researchers will track how well the drugs control skin and joint symptoms and improve quality of life, as well as any side eff…

This study looks at whether changing how much salt you eat can affect sodium levels in the skin and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either salt tablets or placebo pills for several weeks. Researchers will measure skin sodium …

This study aims to create a standard method for collecting and analyzing skin oil (sebum) to find biomarkers for skin diseases like acne, eczema, and psoriasis. Researchers will study 200 participants, including healthy people and those with skin conditions, to see how skin oil c…

This study tests whether letting patients complete monthly health surveys online can help schedule their dermatology appointments more flexibly, instead of fixed visits. About 250 adults with chronic skin conditions like eczema or psoriasis will be randomly assigned to either the…

This study will look at medical records of 350 psoriasis patients in Costa Rica to find out how many also have conditions like obesity, diabetes, heart disease, or psoriatic arthritis. Researchers want to understand how these health problems relate to psoriasis severity and treat…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness (erythema) in psoriasis lesions. Researchers will compare the AI's measurements to those from a standard colorimeter, the current gold standard. The study involves 50…