Can a new daily pill quiet the immune attack behind psoriasis?
NCT ID NCT07724366
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This phase 3 trial is testing an experimental daily capsule called TQH3906 in adults with moderate to severe plaque psoriasis. The drug works by blocking a key immune pathway involved in skin inflammation. Researchers are comparing TQH3906 against a placebo and an approved treatment to see if it can safely clear skin plaques and improve quality of life over 52 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental TYK2 inhibitor called TQH3906, taken as a daily capsule
- What this could lead to
- If it works, TQH3906 could offer a new once-daily oral option for people with moderate to severe plaque psoriasis, potentially clearing skin plaques and improving quality of life.
- What could go wrong
- This is an early-phase 3 trial, so the drug's effectiveness and safety are not yet proven. Possible side effects include immune suppression and infections, and the drug may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hospital of Chengde Medical University
Chengde, Hebei, 067000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, 10010, China
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Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, 212008, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chongqing Traditional Chinese Medicine Hospital
Chongqing, Chongqing Municipality, 400011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dermatology Hospital of Southern Medical University
Guangzhou, Guangdong, 510000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gerneral Hospital of Ningxia Medical Univercity
Yinchuan, The Ningxia Hui Autonomous Region, 750000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 519041, China
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Guizhou Provincial People's Hospital
Guiyang, Guizhou, 550002, China
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Hainan Fifth People's Hospital
Haikou, Hainan, 570100, China
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Heilongjiang Provincial Hospital
Harbin, Heilongjiang, 150036, China
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Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, 200040, China
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Jiaxing First Hospital
Jiaxing, Zhejiang, 314001, China
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Jingzhou Central Hospital
Jingzhou, Hubei, 434020, China
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Jinhua Municipal Central Hospital
Jinhua, Zhejiang, 321000, China
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Jining No.1 People'S Hospital
Jining, Shandong, 272011, China
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Nantong Cancer Hospital
Nantong, Jiangsu, 215004, China
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Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
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Puyang Oilfield General Hospital
Puyang, Henan, 457001, China
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Qilu Hospital Dezhou Branch of Shandong University (Dezhou People's Hospital)
Dezhou, Shandong, 253000, China
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Qingdao Municipal Hospital
Qingdao, Shandong, 266000, China
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Shenyang Seventh People's Hospital (Shenyang Hospital of Integrated Traditional Chinese and Western Medicine, Shenyang Dermatology Hospital)
Shenyang, Liaoning, 110003, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shenzhen Second People's Hospital
Shenzhen, Guangdong, 518032, China
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Shijiazhuang Traditional Chinese Medicine Hospital
Shijiazhuang, Hebei, 050000, China
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Suining Central Hospital
Suining, Sichuan, 629000, China
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Suzhou Municipal Hospital
Suzhou, Jiangsu, 215002, China
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The First Affiliated Hospital of China Medical University
Shenyang, Liaoning, 110002, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Chongqing Medical University 。
Chongqing, Chongqing Municipality, 400010, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, 530021, China
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The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650032, China
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The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, 315020, China
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The First Peopel's Hospital of Zhengzhou
Zhengzhou, Henan, 450004, China
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The First People's Hospital of Lianyungang
Lianyungang, Jiangsu, 222061, China
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The First People's Hospital of Xining
Xining, Qinghai, 810000, China
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The Second Affiliated Hospital of Henan University of science and technology
Luoyang, Henan, 471099, China
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710004, China
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The Second Hospital of Jilin University
Changchun, Jilin, 130000, China
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The Second People's Hospital of ChangZhi
Changzhi, Shanxi, 46000, China
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The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410013, China
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Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital
Tianjin, Tianjin Municipality, 300120, China
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Tianjin First Central Hospital
Tianjin, Tianjin Municipality, 300110, China
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Xiangya Hospital of Central South University
Changsha, Hunan, 410000, China
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Zhengzhou Central Hospital
Zhengzhou, Henan, 450000, China
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Zhongyi Northeast International Hospital Co., Ltd.
Shengyang, Liaoning, 110623, China
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New oral pill HPP737 takes on psoriasis in Head-to-Head trial
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- New oral pill HPP737 aims to clear psoriasis in phase II trial