PSORIASIS

This Phase 2 trial tests whether the oral drug RAP-103 can improve skin clearance and quality of life in people with moderate to severe psoriasis. About 90 adults aged 18 to 70 will take either a daily or twice-daily dose of RAP-103 or a placebo for 8 weeks. The study measures ho…

This Phase 2 trial tests an experimental oral drug called D-2570 in 75 adults with moderate to severe plaque psoriasis. Participants are randomly assigned to receive either D-2570 or a placebo tablet for 12 weeks. The main goal is to see if the drug can achieve at least a 90% imp…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study watches 200 adults with moderate-to-severe plaque psoriasis who have never taken a biologic before. They are starting treatment with guselkumab, and researchers will track how many continue the drug for two years. The goal is to see how well people stick with this trea…

This study tests whether adding a Mediterranean diet (rich in olive oil, nuts, fish, and limited red meat) improves psoriasis symptoms in 36 adults who are about to start biologic therapy (Anti-IL-17 or Anti-IL-23 drugs). Participants are randomly assigned to either follow the di…

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

This study follows 350 adults in France with moderate-to-severe plaque psoriasis who are starting deucravacitinib, a daily pill. Researchers will track how well the drug controls skin symptoms and improves quality of life over time in real-world settings, not a controlled lab env…

This study watches 200 adults with moderate to severe psoriasis who switch from ustekinumab to guselkumab in everyday medical practice. Researchers track how well the new drug clears skin symptoms and check for side effects over 52 weeks. The goal is to see if guselkumab works sa…

This study compares methotrexate alone versus methotrexate plus the antidepressant escitalopram in 40 adults with moderate to severe psoriasis and depression or anxiety. Over six months, researchers will measure skin improvement and mental health changes to see if the combination…

This study compares the effectiveness and safety of different doses and schedules of guselkumab in 400 Chinese adults with moderate to severe plaque psoriasis. Participants will receive either a high dose, an extended-interval dose, or the standard dose. The goal is to find the b…

This study tests whether a daily magnolia bark supplement (Viv) can reduce immune-related blood markers in adults with psoriasis. One hundred participants will take either the supplement or a placebo for three months. Researchers will measure changes in inflammatory proteins and …

This study looks at whether people with psoriasis who are doing very well on the drug guselkumab (Tremfya) can safely wait longer than the usual 8 weeks between injections. Researchers will track 100 adults whose doctors have already extended their dosing intervals to see how the…

This study tests whether applying a solution of Lactobacillus plantarum, a beneficial bacteria from healthy skin, to psoriasis patches can improve the condition. 184 adults with mild-to-moderate psoriasis will apply the bacteria or an inactive version daily for two months. The go…

This study tests a drug called picankibart in teenagers aged 12 to 18 with moderate-to-severe plaque psoriasis. Half get the drug, half get a placebo, and researchers check if their skin clears up after 16 weeks. The goal is to see if it's safe and works better than a dummy treat…

This Phase 1 trial tests a new biosimilar called CKD-704, which is designed to be a more affordable copy of the psoriasis drug Skyrizi (risankizumab). The study involves 213 healthy adults who will receive a single dose of either CKD-704, the EU-approved Skyrizi, or the US-licens…

This study compares two oral medications, methotrexate and tofacitinib, to see which is more effective at reducing psoriasis plaques. It involves 75 adults with moderate to severe chronic plaque psoriasis who have not responded well to topical treatments. The main goal is to meas…

This study follows 200 Italian patients with moderate-to-severe psoriasis who are already taking deucravacitinib, a daily pill that calms the immune system. Researchers will track how well the drug controls skin symptoms, its side effects, and how it affects quality of life in re…

This study tests whether early use of the drug bimekizumab can delay or prevent chronic inflammation in people with mild plaque psoriasis. 40 adults with recent-onset or long-standing mild psoriasis will receive either bimekizumab injections or a topical steroid cream. The goal i…

This study tests whether using a person's unique biomarkers to choose their biologic treatment works better than the standard approach for psoriasis and psoriatic arthritis. About 50 adults in Taiwan will be randomly assigned to either a personalized selection group or a standard…

This study tests whether the drug guselkumab can prevent psoriatic arthritis in people with psoriasis who are at high risk. 176 adults with psoriasis and early signs of joint inflammation will receive either guselkumab or standard care. The goal is to see if the drug can stop art…

This study tests whether a mobile app that provides psychological tools can improve quality of life for people with eczema, psoriasis, or chronic hives. Participants use the app over 32 weeks to learn coping strategies and wellness tips. The goal is to see if this digital approac…

This study tests whether Mindfulness-Based Cognitive Therapy (MBCT) can reduce psychological distress and improve self-compassion in people with psoriasis. Researchers will enroll 128 adults with psoriasis who are experiencing emotional difficulties. Participants will either rece…

This study is testing a new laser called PALLAS to treat skin diseases like vitiligo, psoriasis, alopecia areata, and atopic dermatitis. About 50 people will receive UVB laser treatments twice a week for up to 3 months. The goal is to see if the laser improves the skin condition …

This study explores whether removing wheat and cow's milk from the diet can reduce inflammation and improve skin symptoms in people with mild-to-moderate psoriasis. 82 participants will follow either a wheat- and dairy-free diet or a control diet for 2 months, then some will be r…

This study looks at whether adding treadmill walking to a low-calorie diet can improve psoriasis and polycystic ovary syndrome (PCOS) in women. Forty obese women with both conditions will be split into two groups: one does diet plus walking, the other does diet only. The trial la…

This study tests a new cream made with ceramide, coconut oil, and cholesterol to see if it improves skin hydration, redness, and itch in people with mild skin barrier problems like eczema, psoriasis, or dry skin. 26 adults will apply either the new cream or plain petrolatum twice…

This study will use a new, more sensitive total-body PET scanner to measure inflammation in the skin, joints, and blood vessels of people with psoriasis. Researchers want to see if switching from a typical Western diet to a more balanced diet for 6 weeks can reduce that inflammat…

This study follows 2500 adults with moderate-to-severe plaque psoriasis who are starting a new advanced therapy. Researchers will check their progress at 16 and 24 weeks using questionnaires. The goal is to build a detailed picture of early treatment responses in real-world setti…

This study is collecting skin and blood samples from 830 people with chronic inflammatory skin diseases like psoriasis, eczema, and lupus. Researchers want to find biological markers that can predict how well a person will respond to treatment after one year. The goal is to move …

This study aims to understand how the immune system and skin healing are connected in people with primary immunodeficiency, psoriasis, or eczema, as well as in healthy volunteers. Researchers will collect skin biopsies, blood samples, and optional skin swabs to analyze microbes a…

This study follows 2,500 adults with moderate-to-severe plaque psoriasis who are starting a new advanced therapy. Researchers will collect data at the start and after 2, 4, and 16 weeks to see how quickly the treatment works. The goal is to build a detailed picture of early treat…

This study looks at 40 adults with psoriasis—some with joint pain (psoriatic arthritis) and some without—to compare immune signals in their blood and skin. Researchers want to understand why some people develop joint problems. Participants give blood and skin samples for lab anal…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) affect the body in people with psoriatic arthritis who are overweight or obese. About 45 adults will receive one or both treatments. Researchers will take samples of skin, joint tissue, and f…

This study looks at how the Shingrix vaccine (for shingles) works in people with psoriasis or myelofibrosis who are taking drugs that weaken their immune system. Researchers will compare their immune response to that of similar patients not on these drugs. The goal is to understa…

This study looks at how abnormal blood vessel growth (angiogenesis) contributes to various skin diseases like rosacea, psoriasis, and certain tumors. Researchers will collect skin samples from 85 volunteers aged 16 and older to analyze markers of angiogenesis. The goal is to bett…

This study looks at inflammatory genes in people with psoriasis to better understand the disease. Researchers will take skin samples from 13 adults with psoriasis and measure genes linked to inflammation. The goal is to find markers that could help manage psoriasis in the future.

This study looks for gene markers that could predict how well a person with psoriasis will respond to certain FDA-approved drugs. About 56 participants will try two different psoriasis medications for 8 weeks each, while researchers take blood and skin samples. The goal is to mak…

This study examines whether biologic treatments for moderate-to-severe psoriasis increase the chance of developing or having a return of genital warts. Researchers will review past medical records and follow 600 adults for two years to compare different treatments. They will also…

This study looks at how well people with psoriasis respond when they need several different biologic treatments over time. Researchers will review medical records from 366 adults treated in NHS hospitals to see if each new treatment works as well as the first. No extra visits are…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how the body processes Hemay005 tablets in people with mild or moderate liver problems compared to those with normal liver function. The goal is to find the right dose for patients with liver issues. 24 adults with psoriasis will take a single dose and have th…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…