PSORIASIS

This study is testing a new drug called picankibart to see if it can safely and effectively control moderate-to-severe plaque psoriasis in teenagers. It will involve about 104 adolescents aged 12 to 18. The main goal is to see if the drug significantly clears skin lesions and imp…

This study is testing a new laser device called PALLAS for treating skin conditions that often improve with UV light, including vitiligo, psoriasis, alopecia areata, and eczema. About 50 participants will receive targeted UVB laser treatments twice a week for up to three months. …

This study is observing patients with moderate-to-severe psoriasis who are switching from one injectable medication (ustekinumab) to another (guselkumab) as part of their regular doctor's care. Researchers will follow 200 patients for a year to see how well the new drug controls …

This study is testing if adding the weight-loss medication tirzepatide to an existing psoriasis treatment (ixekizumab) works better for people who have both conditions. It will involve about 200 adults with moderate-to-severe plaque psoriasis who are also overweight or have obesi…

This study is testing whether a medication called bimekizumab, given as injections, can better control early plaque psoriasis and delay it from becoming a chronic, recurring condition compared to standard topical steroid creams. It will involve 40 adults aged 18-45 who have had m…

This study is testing whether a daily over-the-counter supplement made from magnolia bark affects immune system activity in adults with psoriasis. For three months, 100 participants will take either the supplement or a placebo pill and use at-home kits to collect blood samples. R…

This study compares two existing oral medications—methotrexate and tofacitinib—to see which is more effective at reducing psoriasis symptoms. It involves 75 adults with moderate-to-severe plaque psoriasis that hasn't responded well to creams and ointments. Researchers will measur…

This study is testing a personalized approach to select biologic medications for people with psoriasis or psoriatic arthritis. Researchers will use a blood test to predict which biologic drug might work best for each patient, then compare outcomes to standard treatment selection.…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study follows 200 Italian patients with moderate to severe psoriasis who have recently started taking the medication deucravacitinib. Researchers want to see how well the drug works, how safe it is, and how it affects patients' quality of life in a real-world setting, outsid…

This study is testing if adding treadmill walking to a standard treatment plan helps women who have both psoriasis and polycystic ovary syndrome (PCOS). Forty women will follow a low-calorie diet and take medication. Half of them will also walk on a treadmill three times a week. …

This study is testing whether a specific probiotic, Lactobacillus plantarum, can help control psoriasis. Researchers believe an imbalance in skin bacteria may worsen the condition. The trial will compare the probiotic against a placebo in 184 adults with mild-to-moderate psoriasi…

This early-stage study is testing a new foam treatment for scalp and body psoriasis in children. Researchers want to see how much of the medicine gets into the bloodstream and check for any side effects when it's used daily. The study will include 16 children between the ages of …

This study looks at whether adults with moderate-to-severe psoriasis who are responding well to guselkumab (Tremfya) injections can safely receive their treatments less frequently. Researchers are examining real-world data from 100 patients who have already extended their injecti…

This study is testing whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. The coordinator will work with 520 patients aged 40-75 to better manage cholesterol, blood pressure, weight, and other heart health…

This study is testing whether a diet free from wheat and cow's milk products can improve skin symptoms and quality of life for people with mild-to-moderate psoriasis. Researchers are recruiting 82 adults to see if this dietary change reduces inflammation and skin plaques. The stu…

This study is testing a new skin cream to see if it helps with dry, itchy skin conditions like eczema and psoriasis. Researchers will compare it to petroleum jelly, a common moisturizer. About 26 adults will apply one of the creams twice a day for four weeks and have their skin c…

This study aims to understand how well people with severe psoriasis respond when they need to switch between multiple biologic medications. Researchers will analyze existing medical records from NHS patients who have received up to ten different biologic treatments. The goal is t…

This study aims to see if switching to a balanced diet for six weeks can reduce body-wide inflammation in people with psoriasis. Researchers will use a new, highly sensitive full-body PET scanner to measure inflammation in the skin and body before and after the diet change in fiv…

This study aims to understand how often people with psoriasis have hidden heart problems and what puts them at risk. Researchers will follow 1,000 adults with psoriasis, checking their blood for specific markers and performing detailed heart scans. The goal is to find early signs…

This study aims to understand how the body's chemical processes (metabolism) relate to immune system problems that cause skin conditions like eczema and psoriasis. Researchers will collect small skin samples and blood from 300 participants, including people with these conditions …

This early-stage study aims to see if a new, potentially lower-cost version of the psoriasis drug Skyrizi (called CKD-704) behaves similarly in the body. It will compare how healthy adults process a single dose of the new drug versus the original versions from the US and Europe. …

This is a long-term research project gathering health information from 10,000 people in the U.S. to build a detailed picture of brain inflammation and related conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants, including both affected and healthy individual…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study is creating a large registry of patients with conditions like eczema, psoriasis, and alopecia areata to track how treatments work in real-world settings. Researchers will follow 15,000 adults and children over time to understand treatment safety, effectiveness, and how…

This early-stage study aims to understand how a potential psoriasis drug, Hemay005, is processed by the body in people with mild or moderate liver impairment compared to those with normal liver function. It involves 24 participants who will take a single dose. The main goal is to…