Weight-Loss drug tirzepatide could double as psoriasis treatment in new trial

NCT ID NCT06857942

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. Researchers will measure improvements in skin clearance, quality of life, and weight reduction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide
What this could lead to: If successful, adding tirzepatide to standard psoriasis therapy could help people with psoriasis and excess weight achieve clearer skin and significant weight loss.
What could go wrong: This is an early-phase, open-label study with no placebo group, so results may be less reliable. Tirzepatide can cause gastrointestinal side effects, and not all participants may respond.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERWEIGHT OR OBESITY PSORIASIS

Contacts and locations

Locations

Austin Institute for Clinical Research
RECRUITING

Pflugerville, Texas, 78660, United States
Bellaire Dermatology Associates
RECRUITING

Bellaire, Texas, 77401, United States
Bellevue Dermatology Clinic
RECRUITING

Bellevue, Washington, 98104, United States
Care Access - Hoboken
RECRUITING

Hoboken, New Jersey, 07030, United States
Center For Dermatology Clinical Research, Inc.
RECRUITING

Fremont, California, 94538, United States
Center for Clinical Studies
RECRUITING

Houston, Texas, 77004, United States
Center for Clinical Studies
RECRUITING

Webster, Texas, 77598, United States
Columbia Dermatology & Aesthetics
RECRUITING

Columbia, South Carolina, 29212, United States
David Fivenson, MD, PLC
RECRUITING

Ann Arbor, Michigan, 48103, United States
Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
DelRicht Research - Thompson's Station
RECRUITING

Smyrna, Tennessee, 37167, United States
Dermatology Associates of Plymouth Meeting
RECRUITING

Plymouth Meeting, Pennsylvania, 19462, United States
Dermatology and Skin Cancer Specialists, LLC
RECRUITING

Rockville, Maryland, 20850, United States
Dermatology of Seattle
RECRUITING

Burien, Washington, 98168, United States
Encore Medical Research
RECRUITING

Hollywood, Florida, 33024, United States
Equity Medical
RECRUITING

New York, New York, 10023, United States
Equity Medical - Bowling Green
RECRUITING

Bowling Green, Kentucky, 42104, United States
First OC Dermatology Research Inc
RECRUITING

Fountain Valley, California, 92708, United States
Great Lakes Research Group, Inc.
RECRUITING

Bay City, Michigan, 48706, United States
MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research
RECRUITING

Tampa, Florida, 33607, United States
Medical Dermatology Specialists
RECRUITING

Phoenix, Arizona, 85006, United States
Metro Boston Clinical Partners
RECRUITING

Brighton, Massachusetts, 02135, United States
Metropolis Dermatology
RECRUITING

Los Angeles, California, 90017, United States
Modern Research Associates, PLLC
RECRUITING

Dallas, Texas, 75231, United States
NeoClinical Research
RECRUITING

Hialeah, Florida, 33016, United States
Northridge Clinical Trials
RECRUITING

Northridge, California, 91325, United States
Onsite Clinical Solutions - Huntersville
RECRUITING

Huntersville, North Carolina, 28078, United States
Optima Research - Boardman
RECRUITING

Boardman, Ohio, 44512, United States
Oregon Dermatology and Research Center
RECRUITING

Portland, Oregon, 97210, United States
Psoriasis Treatment Center of Central New Jersey
RECRUITING

East Windsor, New Jersey, 08520, United States
Revival Research Institute, LLC
RECRUITING

Cary, North Carolina, 27511, United States
Skin Cancer and Dermatology Institute - Reno
RECRUITING

Reno, Nevada, 89509, United States
Skin Care Research
RECRUITING

Hollywood, Florida, 33021, United States
Southeast Research Specialists
RECRUITING

Douglasville, Georgia, 30135, United States
Stracskin
RECRUITING

Portsmouth, New Hampshire, 03801, United States
Tanner Clinic
RECRUITING

Layton, Utah, 84041, United States
Texas Dermatology and Laser Specialists
RECRUITING

San Antonio, Texas, 78218, United States
The Derm Institute of West Michigan
RECRUITING

Caledonia, Michigan, 49316, United States
The Indiana Clinical Trials Center, PC
RECRUITING

Plainfield, Indiana, 46168, United States
TruDerm & TruSpa
RECRUITING

Wellington, Florida, 33449, United States

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