Weight-Loss drug tirzepatide could double as psoriasis treatment in new trial

NCT ID NCT06857942

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. Researchers will measure improvements in skin clearance, quality of life, and weight reduction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tirzepatide

What this could lead to

If successful, adding tirzepatide to standard psoriasis therapy could help people with psoriasis and excess weight achieve clearer skin and significant weight loss.

What could go wrong

This is an early-phase, open-label study with no placebo group, so results may be less reliable. Tirzepatide can cause gastrointestinal side effects, and not all participants may respond.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Austin Institute for Clinical Research

    RECRUITING

    Pflugerville, Texas, 78660, United States

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  • Bellaire Dermatology Associates

    RECRUITING

    Bellaire, Texas, 77401, United States

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  • Bellevue Dermatology Clinic

    RECRUITING

    Bellevue, Washington, 98104, United States

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  • Care Access - Hoboken

    RECRUITING

    Hoboken, New Jersey, 07030, United States

    Contact Phone: •••-•••-••••

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  • Center For Dermatology Clinical Research, Inc.

    RECRUITING

    Fremont, California, 94538, United States

    Contact Phone: •••-•••-••••

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  • Center for Clinical Studies

    RECRUITING

    Houston, Texas, 77004, United States

    Contact Phone: •••-•••-••••

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  • Center for Clinical Studies

    RECRUITING

    Webster, Texas, 77598, United States

    Contact Phone: •••-•••-••••

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  • Columbia Dermatology & Aesthetics

    RECRUITING

    Columbia, South Carolina, 29212, United States

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  • David Fivenson, MD, PLC

    RECRUITING

    Ann Arbor, Michigan, 48103, United States

    Contact Phone: •••-•••-••••

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  • Dawes Fretzin Clinical Research Group, LLC

    RECRUITING

    Indianapolis, Indiana, 46250, United States

    Contact Phone: •••-•••-••••

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  • DelRicht Research - Thompson's Station

    RECRUITING

    Smyrna, Tennessee, 37167, United States

    Contact Phone: •••-•••-••••

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  • Dermatology Associates of Plymouth Meeting

    RECRUITING

    Plymouth Meeting, Pennsylvania, 19462, United States

    Contact

  • Dermatology and Skin Cancer Specialists, LLC

    RECRUITING

    Rockville, Maryland, 20850, United States

    Contact

  • Dermatology of Seattle

    RECRUITING

    Burien, Washington, 98168, United States

    Contact Phone: •••-•••-••••

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  • Encore Medical Research

    RECRUITING

    Hollywood, Florida, 33024, United States

    Contact Phone: •••-•••-••••

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  • Equity Medical

    RECRUITING

    New York, New York, 10023, United States

    Contact Phone: •••-•••-••••

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  • Equity Medical - Bowling Green

    RECRUITING

    Bowling Green, Kentucky, 42104, United States

    Contact Phone: •••-•••-••••

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  • First OC Dermatology Research Inc

    RECRUITING

    Fountain Valley, California, 92708, United States

    Contact Phone: •••-•••-••••

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  • Great Lakes Research Group, Inc.

    RECRUITING

    Bay City, Michigan, 48706, United States

    Contact Phone: •••-•••-••••

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  • MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research

    RECRUITING

    Tampa, Florida, 33607, United States

    Contact Phone: •••-•••-••••

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  • Medical Dermatology Specialists

    RECRUITING

    Phoenix, Arizona, 85006, United States

    Contact Phone: •••-•••-••••

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  • Metro Boston Clinical Partners

    RECRUITING

    Brighton, Massachusetts, 02135, United States

    Contact

  • Metropolis Dermatology

    RECRUITING

    Los Angeles, California, 90017, United States

    Contact Phone: •••-•••-••••

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  • Modern Research Associates, PLLC

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Phone: •••-•••-••••

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  • NeoClinical Research

    RECRUITING

    Hialeah, Florida, 33016, United States

    Contact Phone: •••-•••-••••

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  • Northridge Clinical Trials

    RECRUITING

    Northridge, California, 91325, United States

    Contact Phone: •••-•••-••••

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  • Onsite Clinical Solutions - Huntersville

    RECRUITING

    Huntersville, North Carolina, 28078, United States

    Contact Phone: •••-•••-••••

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  • Optima Research - Boardman

    RECRUITING

    Boardman, Ohio, 44512, United States

    Contact Phone: •••-•••-••••

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  • Oregon Dermatology and Research Center

    RECRUITING

    Portland, Oregon, 97210, United States

    Contact Phone: •••-•••-••••

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  • Psoriasis Treatment Center of Central New Jersey

    RECRUITING

    East Windsor, New Jersey, 08520, United States

    Contact

  • Revival Research Institute, LLC

    RECRUITING

    Cary, North Carolina, 27511, United States

    Contact

  • Skin Cancer and Dermatology Institute - Reno

    RECRUITING

    Reno, Nevada, 89509, United States

    Contact Phone: •••-•••-••••

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  • Skin Care Research

    RECRUITING

    Hollywood, Florida, 33021, United States

    Contact Phone: •••-•••-••••

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  • Southeast Research Specialists

    RECRUITING

    Douglasville, Georgia, 30135, United States

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  • Stracskin

    RECRUITING

    Portsmouth, New Hampshire, 03801, United States

    Contact Phone: •••-•••-••••

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  • Tanner Clinic

    RECRUITING

    Layton, Utah, 84041, United States

    Contact

  • Texas Dermatology and Laser Specialists

    RECRUITING

    San Antonio, Texas, 78218, United States

    Contact Phone: •••-•••-••••

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  • The Derm Institute of West Michigan

    RECRUITING

    Caledonia, Michigan, 49316, United States

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  • The Indiana Clinical Trials Center, PC

    RECRUITING

    Plainfield, Indiana, 46168, United States

    Contact Phone: •••-•••-••••

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  • TruDerm & TruSpa

    RECRUITING

    Wellington, Florida, 33449, United States

    Contact