New study tests sleep pills to boost knee surgery recovery
NCT ID NCT07598734
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the sleep aids doxepin and ramelteon can improve sleep quality during the first 6 weeks after total knee replacement. About 129 adults will be randomly assigned to take doxepin alone, doxepin plus ramelteon, or a placebo pill each night. The goal is to see if better sleep leads to less pain, better knee function, and improved quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- doxepin and ramelteon
- What this could lead to
- If it works, this could provide a safe, effective option to improve sleep and recovery after knee replacement surgery.
- What could go wrong
- This is a small, early-phase trial (129 people) testing drugs for a short period. Results may not apply to everyone, and side effects or lack of benefit are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Washington Medical Center Hip & Knee Center
Seattle, Washington, 98133, United States