Brain scans reveal why dieting fails?
NCT ID NCT03578887
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study used MRI brain scans in twins to investigate whether brain inflammation (gliosis) plays a role in obesity and weight regain. Researchers compared people undergoing behavioral weight loss, bariatric surgery, and healthy-weight controls. The goal was to understand why weight loss is often temporary and whether surgery resets the brain's weight set point.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could reveal why weight regain is common after dieting and point to new brain-focused treatments for obesity.
What could go wrong
This is an observational study, not a treatment trial. Results may not lead to direct therapies, and findings may not apply to everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Washington - South Lake Union
Seattle, Washington, 98109, United States