Brain scans reveal why dieting fails?
NCT ID NCT03578887
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study used MRI brain scans in twins to investigate whether brain inflammation (gliosis) plays a role in obesity and weight regain. Researchers compared people undergoing behavioral weight loss, bariatric surgery, and healthy-weight controls. The goal was to understand why weight loss is often temporary and whether surgery resets the brain's weight set point.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could reveal why weight regain is common after dieting and point to new brain-focused treatments for obesity.
- What could go wrong
- This is an observational study, not a treatment trial. Results may not lead to direct therapies, and findings may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Washington - South Lake Union
Seattle, Washington, 98109, United States
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