Blood-Derived clots could protect jaw bone after tooth removal
NCT ID NCT07673848
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-strengthening or cancer medications that increase MRONJ risk. The trial uses advanced imaging and protein analysis to track healing over 15 days, with a final check at 180 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
autogenous platelet concentrates (A-PRF)
What this could lead to
If effective, this approach could reduce the risk of jaw bone death after dental extractions in patients taking bone-strengthening or cancer medications.
What could go wrong
This is a small, early-stage study with 44 participants, so results may not apply to all patients. The procedure involves blood draws and centrifugation, and benefits over standard care are not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.