Common pain gel could shield cancer patients from radiation burns

NCT ID NCT06905561

Recruiting now Prevention Sponsor: The Second Affiliated Hospital of Hainan Medical University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a gel containing diclofenac, a common anti-inflammatory drug, can prevent severe skin irritation caused by radiation therapy. About 156 adults with head/neck or breast cancer will apply the gel or a placebo to the treated skin three times daily during their radiation course. The goal is to see if the gel reduces the chance of developing moderate to severe dermatitis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diclofenac sodium gel
What this could lead to: If it works, this could offer a simple, low-cost way to prevent painful skin burns during radiation therapy, helping patients complete treatment without interruption.
What could go wrong: This is a small, early-stage trial at a single center, so results may not apply broadly. The gel may not reduce severe dermatitis better than placebo, and skin irritation or allergic reactions are possible.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm head and neck neoplasm Head and Neck Neoplasms hypopharyngeal carcinoma laryngeal carcinoma nasopharyngeal carcinoma oropharyngeal carcinoma paranasal sinus carcinoma salivary gland carcinoma radiodermatitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HEAD AND NECK TUMOR

Contacts and locations

Locations

The Second Affiliated Hospital of Hainan Medical University
RECRUITING

Haikou, Hainan, 570311, China

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