Ureterolithiasis

This study tests a new device called the Enhanced Lithotripsy System (ELS) that uses low-pressure ultrasound to activate tiny bubbles in the urine, breaking kidney or ureter stones into small pieces that can pass naturally. The trial will enroll 101 adults with a single stone in …

This study looks at people with a sudden kidney blockage from a stone in their only working kidney. Doctors will randomly use either a tube placed through the bladder or one through the back to drain urine. The goal is to see which method helps kidney function recover better and …

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This study compares two types of lasers used to break up kidney stones during a minimally invasive procedure called ureteroscopy. One laser uses a superpulse thulium fiber (sTFL), the other is a standard holmium laser. Researchers will enroll 136 adults aged 18–70 with kidney sto…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study is testing a new type of ureteral stent that is designed to slowly dissolve and pass out of the body on its own after being placed during kidney stone surgery. The goal is to see if it safely drains urine and breaks down within 90 days, so patients don't need a second …

This trial tests a new device called VISOR for removing kidney stones. It combines stone breaking, suction, and pressure control in one tool. About 20 adults with 1-3 cm stones will undergo surgery with VISOR. The goal is to see if it clears stones safely and effectively, with a …

This study tests two medications, mirabegron and tamsulosin, to see which works best for helping people pass ureteral stones and reducing pain. 500 adults with stones between 4-10 mm will be randomly assigned to one of four groups: mirabegron alone, tamsulosin alone, both drugs t…

This study tests two different ways of positioning patients during surgery for stones in the upper part of the ureter. One position uses a slight head-down tilt to keep stones from moving back into the kidney, while the other tilts the patient to help clear stones from the kidney…

This study compares a new type of ureteral stent (ComfiJ) with a standard Double-J stent in 150 adults who need a short-term stent after kidney stone surgery. The goal is to see if the ComfiJ stent causes fewer urinary symptoms, like pain or urgency, two weeks after surgery. Part…

This study tests whether putting a drug called aminophylline into the bladder before placing a ureteral stent helps doctors get the stent past a blocking stone more easily. The trial involves 72 adults with sudden kidney failure from stones in a single working kidney. Half get th…

This study compares L-citrulline, an amino acid, to tamsulosin, a standard drug, for helping adults pass kidney stones. 120 people with a single stone in the lower ureter will take one of the two treatments for up to 4 weeks. The main goal is to see which treatment leads to faste…

This study tests if a drug called aminophylline, placed directly into the bladder, can help doctors insert a small scope to remove kidney stones in children. About 60 children aged 2 to 17 with a stone in the lower ureter will take part. If the first gentle attempt to pass the sc…

This study compares melatonin, solifenacin, and their combination to reduce bothersome urinary symptoms and pain caused by a temporary ureteral stent placed after kidney stone surgery. About 189 adults will take one of the two drugs or both for 14 days. The goal is to see which a…

This study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…

This study tests whether combining tamsulosin with either a standard or half dose of tadalafil can better relieve symptoms caused by ureteric stents, such as pain, urgency, and discomfort. Researchers will enroll 140 adults who have a stent placed after kidney stone removal. The …

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests a new flexible suction sheath (FANS) against the traditional sheath for kidney stone removal surgery. About 80 adults with small-to-medium kidney stones will be randomly assigned to one of the two tools. The main goal is to see which tool leaves fewer stone fragm…

This study tests whether taking the steroid prednisone after ureteroscopy (a surgery for kidney stones) can help reduce pain and the need for other pain medications. Researchers will enroll 90 adults who are having this surgery with a stent placed. The goal is to see if adding a …

This study looks at whether leaving a stent out after kidney stone surgery can reduce pain and the need for extra medical visits. About 184 adults with kidney or ureteral stones will be randomly assigned to either get a stent or not after their procedure. Researchers will track p…

This study looks at whether it is safe and less painful to skip placing a temporary tube (stent) after routine kidney stone removal. About 792 adults with small stones will either get a stent or not, and researchers will track pain and any unplanned doctor visits. The goal is to …

This study compares two minimally invasive procedures—semi-rigid and flexible ureteroscopy—for removing upper ureter stones smaller than 2 cm. Researchers will measure which method clears stones more effectively, how long the surgery takes, and overall costs. The trial enrolls 10…

This study tests whether two common blood pressure drugs, terazosin and tamsulosin, can reduce urinary symptoms like pain and urgency after a ureteral stent is placed. 150 adults in Malaysia will be randomly assigned to take one of the drugs or receive standard care for 14 days. …

This study is looking for factors that might predict inflammatory polyps in the ureter (the tube from kidney to bladder) in people with kidney stones. Researchers will review past patient data and then test their predictions on new patients. The goal is to create a simple tool th…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This study compares two approaches after ureteroscopy for ureteral stones: placing a temporary stent (a small tube) or leaving it out. Researchers want to see if skipping the stent reduces pain and complications. Sixty adults with ureteral stones will be randomly assigned to one …

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…