Bubble blast: new device aims to shatter kidney stones without surgery

NCT ID NCT06942949

Recruiting now Disease control Sponsor: Avvio Medical Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new device called the Enhanced Lithotripsy System (ELS) that uses low-pressure ultrasound to activate tiny bubbles in the urine, breaking kidney or ureter stones into small pieces that can pass naturally. The trial will enroll 101 adults with a single stone in the ureter. Participants receive the ELS procedure and are checked with a CT scan 30 days later to see if the stone is gone or reduced to fragments small enough to pass.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enhanced Lithotripsy System (ELS) device with microbubbles
What this could lead to: If it works, this could offer a less painful way to break up urinary stones so they pass naturally, reducing the need for surgery.
What could go wrong: This is a small, early-stage trial with only 101 people. The device may not break stones effectively for everyone, and some may still need additional procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi Ureteral Calculi ureterolithiasis urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY CALCULI; URETERAL CALCULI

Contacts and locations

Locations

Arizona State Urological Research Institute
RECRUITING

Phoenix, Arizona, 85225, United States
Arkansas Urology Research Center
ENROLLING_BY_INVITATION

Little Rock, Arkansas, 72211, United States
Comprehensive Urologic Care
RECRUITING

Lake Barrington, Illinois, 60010, United States
Duke
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Georgia Urology
RECRUITING

Roswell, Georgia, 300076, United States
Golden State Urology
RECRUITING

Sacramento, California, 95823, United States
Michael G. Oefelein Clinical Trials
ACTIVE_NOT_RECRUITING

Bakersfield, California, 93301, United States
Minnesota Urology
RECRUITING

Woodbury, Minnesota, 55125, United States
Nebraska Urology
ENROLLING_BY_INVITATION

Lincoln, Nebraska, 68516, United States
SUNY - Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
San Diego Clinical Trials
RECRUITING

La Mesa, California, 91942, United States
University of Miami Hospital
RECRUITING

Miami, Florida, 33136, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14620, United States
University of Virginia
WITHDRAWN

Charlottesville, Virginia, 22903, United States
University of Virginia Community Health
ACTIVE_NOT_RECRUITING

Culpeper, Virginia, 22701, United States
Urology Nevada
ENROLLING_BY_INVITATION

Reno, Nevada, 89511, United States
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Urology Specialists Clinic
ENROLLING_BY_INVITATION

Sioux City, South Dakota, 57108, United States
Urology of Virginia
RECRUITING

Virginia Beach, Virginia, 23462, United States
Wichita Urology Group
RECRUITING

Wichita, Kansas, 67226, United States

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