Massive study probes cancer risk of common diabetes drug

NCT ID NCT02695121

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 years. The goal is to better understand the long-term safety of dapagliflozin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

dapagliflozin

What this could lead to

If this study finds no increased cancer risk, it could reassure patients and doctors that dapagliflozin is safe to use for type 2 diabetes.

What could go wrong

This is an observational study, not a controlled trial, so it can only show links, not cause and effect. Results may be influenced by other factors like patient health or lifestyle.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm type 2 diabetes mellitus urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Wilmington, Delaware, United States

  • Research Site

    Washington D.C., District of Columbia, United States

  • Research Site

    Utrecht, Netherlands

  • Research Site

    London, United Kingdom