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New bladder pain pill shows promise in early trial

NCT ID NCT06752603

Completed Symptom relief Sponsor: Ono Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This Phase 2 trial tests whether a once-daily tablet called ONO-1110 can safely reduce bladder pain in people with Hunner type interstitial cystitis, a painful bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to see if pain scores improve compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ONO-1110 (tablet taken once daily)
What this could lead to
If successful, this could point toward a new daily pill to ease chronic bladder pain in people with Hunner type interstitial cystitis.
What could go wrong
This is an early Phase 2 trial with only 50 participants in Japan, so results may not apply to other groups. The drug may not reduce pain better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

interstitial cystitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNNER TYPE INTERSTITIAL CYSTITIS

Contacts and locations

Locations

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, Japan

  • Harasanshin Hospital

    Fukuoka, Fukuoka, Japan

  • Izumi Chuo Hospital

    Sendai, Miyagi, Japan

  • Japanese Red Cross Gifu Hospital

    Gifu, Gifu, Japan

  • Kanto Rosai Hospital

    Kawasaki, Kanagawa, Japan

  • Kurosawa Hospital Health Park Clinic

    Takasaki, Gunma, Japan

  • Kyorin University Hospital

    Mitaka, Tokyo, Japan

  • Nagasaki University Hospital

    Nagasaki, Japan

  • Nagoya University Hospital

    Nagoya, Aichi-ken, Japan

  • Nakamura Hospital

    Beppu, Oita Prefecture, Japan

  • Nanri Urological Clinic

    Saga, Saga-ken, Japan

  • Niimura Hospital

    Kagoshima, Kagoshima-ken, Japan

  • Okayama University Hospital

    Okayama, Okayama-ken, Japan

  • Rakuwakai Marutamachi Hospital

    Kyoto, Kyoto, Japan

  • Shinshu University Hospital

    Matsumoto, Nagano, Japan

  • The Jikei University Hospital

    Minato-Ku, Tokyo, Japan

  • The University Of Tokyo Hospital

    Tokyo, Tokyo, Japan

  • Toyama Rosai Hospital

    Uozu, Toyama, Japan

  • Ueda Clinic

    Kyoto, Kyoto, Japan

  • University Of Yamanashi Hospital

    Chūō, Yamanashi, Japan

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