New bladder pain pill shows promise in early trial
NCT ID NCT06752603
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 38 times
Summary
This Phase 2 trial tests whether a once-daily tablet called ONO-1110 can safely reduce bladder pain in people with Hunner type interstitial cystitis, a painful bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to see if pain scores improve compared to placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Fukushima Medical University Hospital
Fukushima, Fukushima, Japan
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Harasanshin Hospital
Fukuoka, Fukuoka, Japan
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Izumi Chuo Hospital
Sendai, Miyagi, Japan
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Japanese Red Cross Gifu Hospital
Gifu, Gifu, Japan
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Kanto Rosai Hospital
Kawasaki, Kanagawa, Japan
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Kurosawa Hospital Health Park Clinic
Takasaki, Gunma, Japan
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Kyorin University Hospital
Mitaka, Tokyo, Japan
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Nagasaki University Hospital
Nagasaki, Japan
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Nagoya University Hospital
Nagoya, Aichi-ken, Japan
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Nakamura Hospital
Beppu, Oita Prefecture, Japan
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Nanri Urological Clinic
Saga, Saga-ken, Japan
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Niimura Hospital
Kagoshima, Kagoshima-ken, Japan
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Okayama University Hospital
Okayama, Okayama-ken, Japan
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Rakuwakai Marutamachi Hospital
Kyoto, Kyoto, Japan
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Shinshu University Hospital
Matsumoto, Nagano, Japan
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The Jikei University Hospital
Minato-Ku, Tokyo, Japan
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The University Of Tokyo Hospital
Tokyo, Tokyo, Japan
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Toyama Rosai Hospital
Uozu, Toyama, Japan
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Ueda Clinic
Kyoto, Kyoto, Japan
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University Of Yamanashi Hospital
Chūō, Yamanashi, Japan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ONO-1110 (tablet taken once daily)
What this could lead to
If successful, this could point toward a new daily pill to ease chronic bladder pain in people with Hunner type interstitial cystitis.
What could go wrong
This is an early Phase 2 trial with only 50 participants in Japan, so results may not apply to other groups. The drug may not reduce pain better than placebo, and side effects are still being studied.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.