Ono Pharmaceutical Co., Ltd.

This study tests if the drug tirabrutinib works better than a combination of two standard drugs (rituximab and temozolomide) for people with a rare type of brain lymphoma that has returned or not responded to prior therapy. About 132 adults with this condition will be randomly as…

This early-stage study tests the safety and tolerability of a new drug called ONO-7428 in adults with advanced solid tumors that have not responded to standard treatments. About 60 participants will receive the drug in increasing doses to find the safest dose. The goal is to unde…

This study tests a drug called ONO-4538 in 23 people aged 1 year and older with rhabdoid tumor, a rare and aggressive cancer. Participants must have tried at least one chemotherapy that stopped working or caused side effects. The main goal is to see if the drug shrinks tumors, wi…

This study tests whether adding an experimental drug (ONO-4578) to standard chemotherapy and immunotherapy can shrink tumors better than standard care alone in people with a specific type of advanced colorectal cancer. About 144 adults whose cancer has spread and who have not had…

This early-stage study is testing a new drug called ONO-4685 in people with T cell lymphoma that has returned or hasn't responded to previous treatments. Researchers will give increasing doses to about 217 patients to find the safest amount and see if the drug shows any signs of …

This study is testing an investigational drug called ONO-4059 for people with pemphigus, a serious autoimmune disease that causes painful skin blisters, who have not responded well to standard steroid treatment. About 34 participants will be randomly assigned to receive either th…

This study tests an experimental drug called ONO-2020 to see if it can safely reduce agitation in people with Alzheimer's disease. About 90 participants in Japan will receive either the drug or a placebo. The goal is to improve quality of life by easing symptoms like restlessness…