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New hope for tough lymphoma: experimental drug ONO-4685 enters human testing

NCT ID NCT05079282

Recruiting now Disease control Sponsor: Ono Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called ONO-4685 in people with T cell lymphoma that has returned or not responded to prior treatments. The main goals are to check the drug's safety and find the best dose. About 217 adults will take part across multiple centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Recurrence T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED OR REFRACTORY T CELL LYMPHOMA

Contacts and locations

Locations

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Hackensack University Medical Center - John Theurer Cancer Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Karmanos Cancer Institute

    RECRUITING

    Detroit, Michigan, 48201, United States

  • MD Anderson

    RECRUITING

    Houston, Texas, 77030, United States

  • Memorial Sloan-Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • New York-Presbyterian/Columbia University Irving Medical Center - Herbert Irving Comprehensive Cancer Center (HICCC)

    RECRUITING

    New York, New York, 10032, United States

  • Novant Health Presbyterian Medical Center

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Oregon Health & Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

  • Stanford Cancer Institute

    RECRUITING

    Palo Alto, California, 94304, United States

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • University of Alabama at Birmingham

    COMPLETED

    Birmingham, Alabama, 35294, United States

  • University of California Irvine Medical Center - Chao Family Comprehensive Cancer Center

    RECRUITING

    Orange, California, 92868, United States

  • University of Pennsylvania - Perelman Center

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Vanderbilt University - Ingram Cancer Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Washington University School of Medicine in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Winship Cancer Institute of Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Yale Cancer Center

    RECRUITING

    New Haven, Connecticut, 06519, United States

More trials for these conditions

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