Ono Pharmaceutical Co., Ltd.

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This study tests a drug called ONO-4538 in 23 people aged 1 year and older with rhabdoid tumor, a rare and aggressive cancer. Participants must have tried at least one chemotherapy that stopped working or caused side effects. The main goal is to see if the drug shrinks tumors, wi…

This study tests a new drug called ONO-4059 for people with pemphigus, a rare autoimmune disease that causes painful blisters on skin and mucous membranes. The trial includes 34 adults whose disease is not well controlled by steroids alone. Participants will receive either ONO-40…

This study is testing a medicine called cenobamate (ONO-2017) in Japanese children aged 2 to 17 who have partial onset seizures that are not well controlled by current treatments. The goal is to see if the drug is safe and can reduce seizure frequency. About 20 children will take…

This early-phase study tests a new drug called ONO-7428 in about 60 adults with advanced solid tumors that have not responded to standard treatments. The main goal is to see if the drug is safe and tolerable, and to find the right dose. Participants will receive the drug and be m…

This early-stage study tests a new drug called ONO-4685 in people with T-cell lymphoma that has returned or not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 217 adults will take part ac…

This study tests a new drug called sapablursen for people with polycythemia vera, a condition where the body makes too many red blood cells. The goal is to see if adding sapablursen to standard treatment can reduce the need for regular blood removal (phlebotomy) and improve sympt…

This study tests whether adding an experimental drug (ONO-4578) to a standard chemotherapy and immunotherapy combination can shrink tumors better than the usual treatment in people with advanced colorectal cancer that has not spread widely. About 144 adults whose tumors show a sp…

This study tests a drug called ONO-4538 in 14 people with Richter's transformation, an aggressive blood cancer that can arise from chronic lymphocytic leukemia. The goal is to see if the drug shrinks tumors and improves survival. Participants must have a specific type of Richter'…

This study compares a new targeted drug, tirabrutinib, with a standard combination of two chemotherapy drugs (rituximab and temozolomide) in 132 people whose primary central nervous system lymphoma has returned or not responded to prior treatment. The main goal is to see which ap…

This study tests an experimental drug called ONO-2020 to see if it can safely reduce agitation in people with Alzheimer's disease. About 90 participants in Japan will receive either the drug or a placebo. The goal is to improve symptoms like restlessness and aggression without cu…

This study reviews medical records of 100 adults in Taiwan with resectable non-small cell lung cancer who received nivolumab (an immunotherapy) combined with chemotherapy before surgery. Researchers want to see if this approach helps shrink tumors completely and delays cancer ret…