Ono Pharmaceutical Co., Ltd.

This phase 3 trial is testing whether the oral targeted drug tirabrutinib works better than a standard combination of rituximab and temozolomide for people with relapsed or refractory primary central nervous system lymphoma (PCNSL). About 132 participants will be randomly assigne…

This phase 2 trial is testing the immunotherapy drug nivolumab in 23 people aged 1 year and older with advanced or recurrent rhabdoid tumors that have not responded to chemotherapy. The goal is to see if the drug can shrink tumors and improve survival. Participants receive nivolu…

This early-stage study tests the safety of an experimental drug called DCC-2618 in 10 people with advanced gastrointestinal stromal tumor (GIST) that has not responded to or cannot tolerate at least three prior treatments. The main goal is to see what side effects occur. This is …

This Phase 2 trial tests whether adding an experimental drug (ONO-4578) and an immunotherapy (Opdivo) to standard chemotherapy and bevacizumab can shrink tumors better than standard care alone in people with advanced colorectal cancer that is not MSI-high and has PD-L1 expression…

This phase 3 trial tests whether adding the drug sapablursen to standard treatment helps people with polycythemia vera, a blood disorder causing too many red blood cells. About 250 participants who currently need regular blood removal (phlebotomy) will receive either sapablursen …

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This study tests a drug called cenobamate in 20 Japanese children aged 2 to 17 who have partial-onset seizures that are not fully controlled by current treatments. The main goal is to see if the drug is safe and tolerable. Participants will take cenobamate tablets daily, with dos…

This early-stage study tests a new drug called ONO-4685 in people with T cell lymphoma that has returned or not responded to prior treatments. The main goals are to check the drug's safety and find the best dose. About 217 adults will take part across multiple centers.

This phase 2 trial tests the drug nivolumab (Opdivo) in 14 people with Richter's transformation, a rare and aggressive blood cancer that arises from chronic lymphocytic leukemia. The study measures how many patients respond to treatment, how long they live, and safety. All partic…

This study tests an experimental drug called ONO-2020 to see if it can safely reduce agitation in people with Alzheimer's disease dementia. About 90 participants in Japan will receive either the drug or a placebo daily for several weeks. Researchers will measure changes in agitat…

This study reviews medical records of 100 adults in Taiwan with resectable non-small cell lung cancer who received nivolumab (an immunotherapy) combined with chemotherapy before surgery. Researchers want to see if this approach helps shrink tumors completely and delays cancer ret…