Ono Pharmaceutical Co., Ltd.

This study tests an experimental drug called ONO-2808 in people with multiple system atrophy (MSA), a rare and serious brain disorder. The goal is to see if the drug is safe and can help control the disease. About 92 adults with early-stage MSA will take either the drug or a plac…

This study tests a new drug, ONO-4578, added to standard immunotherapy and chemotherapy for people with advanced stomach cancer that cannot be removed by surgery. The goal is to see if the combination helps control the cancer longer. About 226 participants who have not had chemot…

This study tests a new drug called ONO-2020 in 240 people with mild to moderate Alzheimer's disease. The goal is to see if it can safely improve memory and thinking. Participants will receive either the drug or a placebo for 26 weeks, and researchers will monitor side effects and…

This study tests an oral drug called tirabrutinib for primary central nervous system lymphoma (PCNSL), a rare cancer in the brain. It includes 119 adults whose cancer returned after prior treatment (Part A) or who are newly diagnosed (Part B). The goal is to see if the drug shrin…

This study tests a new medicine called ONO-1110 to see if it can safely reduce pain in people with fibromyalgia. About 160 Japanese adults will receive either the drug or a placebo for 8 weeks. The main goal is to measure changes in average pain scores and watch for side effects.

This study tests a new medicine called ONO-1110 to see if it can reduce symptoms of social anxiety disorder. About 100 Japanese adults with social anxiety will receive either the drug or a placebo for 12 weeks. The main goal is to measure changes in anxiety levels using a standar…

This study tests whether ONO-1110 can safely reduce pain and urinary symptoms in people with Hunner type interstitial cystitis, a chronic bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to see if average daily p…

This study tests a new medicine called ONO-1110 to see if it can help people with major depressive disorder. About 100 Japanese adults will receive either the drug or a placebo for 8 weeks. Researchers will measure changes in depression symptoms using a standard rating scale.

This study tests a new medicine called ONO-1110 for people with long-term nerve pain after shingles (postherpetic neuralgia). About 140 Japanese adults will receive either the drug or a placebo to see if it safely reduces pain over 8 weeks. The goal is to find a better way to eas…

This study looks at how the drug tirabrutinib moves through the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. About 40 adults aged 18 to 75 will take part. The goal is to understand how liver function affects drug levels and s…