Ono Pharmaceutical Co., Ltd.

This study tests whether adding an experimental drug (ONO-4578) to standard chemotherapy and immunotherapy can help people with advanced HER2-negative stomach cancer live longer without their disease getting worse. About 226 adults who have not had chemotherapy before will take p…

This study tests an experimental drug called ONO-2808 in 92 people with Multiple System Atrophy (MSA), a rare and serious brain disorder that affects movement and body functions. The goal is to see if the drug is safe and how the body processes it. Participants will receive eithe…

This study is testing a drug called tirabrutinib for a rare and aggressive cancer that starts in the brain or spinal cord, called primary central nervous system lymphoma (PCNSL). It has two parts: one for patients whose cancer has come back or didn't respond to prior treatment, a…

This study is testing whether a new drug called ONO-2020 can help improve memory and thinking skills in people with mild to moderate Alzheimer's disease. Researchers will give the drug or a placebo to 240 participants for 26 weeks to see if it's safe and if it helps with cognitiv…

This study is testing an investigational drug called ONO-1110 to see if it can safely reduce symptoms of major depressive disorder. It will involve about 100 Japanese adults with moderate-to-severe depression, comparing the drug against a placebo over 8 weeks. The main goal is to…

This study tests a new medicine called ONO-1110 to see if it helps reduce anxiety in people with social anxiety disorder. About 100 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to measure changes in social anxiety symptoms using a stand…

This study tests a new medicine called ONO-1110 to see if it can safely reduce pain in people with fibromyalgia. About 160 Japanese adults with fibromyalgia will receive either the drug or a placebo for 8 weeks. The main goal is to measure changes in average weekly pain scores an…

This study tests a new medicine called ONO-1110 to see if it can safely reduce pain in people with Hunner type interstitial cystitis, a painful bladder condition. About 50 Japanese adults will receive either the drug or a placebo for 12 weeks. The main goal is to measure changes …

This study is testing an investigational drug called ONO-1110 to see if it can safely reduce persistent nerve pain that lingers after a shingles rash has healed, a condition called postherpetic neuralgia. It will involve about 140 Japanese adults who have had this pain for at lea…

This study looks at how the drug tirabrutinib moves through the body in people with mild, moderate, or severe liver problems compared to those with healthy livers. About 40 adults aged 18 to 75 will take part. The goal is to understand how liver function affects drug levels and s…