New oral drug takes on tough brain cancer in phase 3 trial
NCT ID NCT07104032
First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 6 times
Summary
This phase 3 trial is testing whether the oral targeted drug tirabrutinib works better than a standard combination of rituximab and temozolomide for people with relapsed or refractory primary central nervous system lymphoma (PCNSL). About 132 participants will be randomly assigned to receive either tirabrutinib alone or the combination therapy. The main goal is to see how long the cancer stays under control, with secondary goals including overall response and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tirabrutinib (a targeted cancer pill)
- What this could lead to
- If it works, this could offer a more convenient oral treatment option for people with relapsed brain lymphoma, potentially improving survival without the need for combination chemotherapy.
- What could go wrong
- This is still an early-stage comparison in a rare cancer, so results may not apply broadly. Tirabrutinib may cause side effects like bleeding or infection, and it's not yet proven to be better than the standard combination therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ASST Spedali Civili di Brescia
RECRUITINGBrescia, Italy, 25123, Italy
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Atlantic Health Overlook Medical Center
RECRUITINGSummit, New Jersey, 07901, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02115, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02115, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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HonorHealth Cancer Center
RECRUITINGScottsdale, Arizona, 85251, United States
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Hospital Center University De Montpellier
RECRUITINGMontpellier, France, 34090, France
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Hospital Clínic de Barcelona
RECRUITINGBarcelona, Spain, Spain
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Hospital Universitario 12 De Octubre
RECRUITINGMadrid, Spain, 28041, Spain
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Hôpitaux de Marseille
RECRUITINGMarseille, France, 13005, France
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John Hopkins University
RECRUITINGWashington D.C., District of Columbia, 20016, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Cancer Center
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic Cancer Center
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Cancer Center
RECRUITINGRochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Penn State Health Milton S Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
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Providence Medical Foundation
RECRUITINGFullerton, California, 92835, United States
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Providence Neurological Specialties West
RECRUITINGPortland, Oregon, 97225, United States
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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UC Irvine Health
RECRUITINGOrange, California, 92868, United States
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University Hospital Ostrava
RECRUITINGOstrava, Czechia, 708 52, Czechia
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University of Florida Gainesville
RECRUITINGGainesville, Florida, 32610, United States
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University of Maryland
RECRUITINGBaltimore, Maryland, 21201, United States
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06520, United States
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