New combo aims to beat bladder cancer without removing the bladder
NCT ID NCT07296705
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a combination of two targeted drugs (zanidatamab and tislelizumab) plus chemotherapy can shrink HER2-positive muscle-invasive bladder cancer enough to avoid bladder removal. About 25 adults with stage T2-T4a bladder cancer will receive the treatment before deciding if the bladder can be safely preserved. The goal is to keep the bladder intact while controlling the cancer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated Hospital of Putian University
RECRUITINGPutian, Fujian, 351106, China
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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Fujian Medical University Union Hospital
RECRUITINGFuzhou, Fujian, 350001, China
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Fujian Provincial Hospital Affiliated to Fuzhou University
RECRUITINGFuzhou, Fujian, 350001, China
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Jiangxi Cancer Hospital
RECRUITINGNanchang, Jiangxi, 330029, China
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Quanzhou First Hospital Affiliated to Fujian Medical University
RECRUITINGQuanzhou, Fujian, 362002, China
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Sanming First Hospital
RECRUITINGSanming, Fujian, 365099, China
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Shandong Cancer Hospital
RECRUITINGJinan, Shandong, 250117, China
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The First Affi liated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, 361003, China
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The First Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, Zhejiang, 325035, China
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Zhangzhou Affiliated Hospital to Fujian Medical University
RECRUITINGZhangzhou, Fujian, 363000, China
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, 310005, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple blood draw could spot bladder Cancer's return
- Bladder preservation: a viable alternative to radical surgery?
- New drug duo aims to wipe out bladder tumors before surgery
- New bladder cancer combo shows promise in Pre-Surgery trial
- Promising combo aims to shrink bladder tumors before surgery
- Which scan is better for bladder cancer staging? new study aims to find out