New drug cocktail aims to wipe out bladder cancer before surgery
NCT ID NCT07693959
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether combining the targeted drug disitamab vedotin (RC48) with chemotherapy (gemcitabine) before surgery works as well as RC48 plus an immunotherapy (toripalimab) for people with HER2-positive muscle-invasive bladder cancer. Participants receive one of the two combos for 3–6 cycles, then undergo bladder removal surgery. The main goal is to see how many patients have no cancer left in the removed tissue. The study also tracks side effects and long-term outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Disitamab vedotin (RC48) and gemcitabine
- What this could lead to
- If successful, this combination could become a standard pre-surgery treatment for HER2-positive muscle-invasive bladder cancer, potentially increasing the chance of eliminating all cancer before surgery.
- What could go wrong
- This is an early-phase comparison; the experimental arm may not prove superior or even non-inferior to the comparator. Side effects from chemotherapy and targeted therapy can be significant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
RECRUITINGShenzhen, Guangdong, 518117, China
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Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, 430030, China
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Fujian Medical University Union Hospital
RECRUITINGFuzhou, Fujian, 350001, China
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Huanggang Central Hospital
RECRUITINGHuanggang, Hubei, 438000, China
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Huangshi Central Hospital
RECRUITINGHuangshi, Hubei, 435000, China
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Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, 430079, China
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Jiangxi Provincial People's Hospital
RECRUITINGNanchang, Jiangxi, 330006, China
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Jingmen Central Hospital
RECRUITINGJingmen, Hubei, 448000, China
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Jingzhou Central Hospital
RECRUITINGJingzhou, Hubei, 434020, China
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Jingzhou First People's Hospital
RECRUITINGJingzhou, Hubei, 434000, China
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Renmin Hospital of Wuhan University
RECRUITINGWuhan, Hubei, 430060, China
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Shandong Cancer Hospital and Institute
RECRUITINGJinan, Shandong, 250117, China
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Taihe Hospital
RECRUITINGShiyan, Hubei, 442000, China
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The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
RECRUITINGEnshi, Hubei, 445000, China
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The Central Hospital of Wuhan
RECRUITINGWuhan, Hubei, 430014, China
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The First Affiliated Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, 230022, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, 361003, China
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Wuhan No.1 Hospital
RECRUITINGWuhan, Hubei, 430022, China
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Xiangyang Central Hospital
RECRUITINGXiangyang, Hubei, 441021, China
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Yichang Central People's Hospital
RECRUITINGYichang, Hubei, 443003, China
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Zhongnan Hospital of Wuhan University
RECRUITINGWuhan, Hubei, 430071, China
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Zhujiang Hospital of Southern Medical University
RECRUITINGGuangzhou, Guangdong, 510280, China
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