New trial tests smarter bladder cancer surgery to save Men's sexual health

NCT ID NCT05792722

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two surgical approaches for removing the bladder in men with bladder cancer: prostate capsule-sparing and nerve-sparing. The goal is to see which technique better preserves erectile function and urinary control. Seventy men will be randomly assigned to one of the two procedures and will complete questionnaires about their sexual and urinary health over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prostate capsule-sparing radical cystectomy and nerve-sparing radical cystectomy
What this could lead to: If successful, this could show that a prostate-sparing surgery helps men maintain better erectile and urinary function after bladder removal, without increasing cancer risk.
What could go wrong: This is a small, early-stage trial (70 participants) comparing two surgical procedures. It is not testing a new drug or cure, and results may not apply to all bladder cancer patients.

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Conditions

The condition(s) this trial relates to.

urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER

Contacts and locations

Locations

Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States

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