New pill could fight bladder cancer without surgery

NCT ID NCT06995677

Recruiting now Disease control Sponsor: Tyra Biosciences, Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 8 times

Summary

This Phase 2 trial tests an oral drug called TYRA-300 in 90 adults with a low-grade, intermediate-risk bladder cancer that has not invaded muscle. The cancer must have a specific genetic change (FGFR3 alteration). Participants take a daily tablet for up to 2 years. The main goal is to see if the drug can make the tumor disappear completely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TYRA-300 (oral tablet)
What this could lead to: If successful, this could provide a new oral treatment option for a specific type of bladder cancer, potentially delaying or avoiding surgery.
What could go wrong: This is an early Phase 2 trial with only 90 participants, so results may not apply to all patients. Side effects are still being studied, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FGFR GENE ALTERATIONS FGFR GENE AMPLIFICATION FGFR3 GENE ALTERATION FGFR3 GENE FUSIONS FGFR3 GENE MUTATION LOW-GRADE NMIBC

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ASL Napoli 2 Nord - Ospedale Santa Maria delle Grazie
RECRUITING

Pozzuoli, 80078, Italy
Arkansas Urology
RECRUITING

Little Rock, Arkansas, 72211, United States
Associate Urologist of North Carolina
RECRUITING

Raleigh, North Carolina, 27612, United States
Associated Medical Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States
Associated Urological Specialists
RECRUITING

Chicago Ridge, Illinois, 60415, United States
Atlantic Health System
RECRUITING

Morristown, New Jersey, 07960, United States
Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara
RECRUITING

Pisa, 56126, Italy
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Conrad Pearson-Memphis
RECRUITING

Germantown, Tennessee, 38138, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27705, United States
Duly Health and Care
RECRUITING

Lisle, Illinois, 60532, United States
Eisenhower Medical Associates
RECRUITING

Rancho Mirage, California, 92270, United States
Epworth Freemasons-Victoria Parade
RECRUITING

Richmond, Victoria, 3121, Australia
First Urology
RECRUITING

Jeffersonville, Indiana, 47130, United States
Greater Boston Urology
RECRUITING

Plymouth, Massachusetts, 02360, United States
Hospital Clínico San Carlos
WITHDRAWN

Madrid, Spain, 28040, Spain
Hospital Quirón Barcelona
RECRUITING

Barcelona, 08908, Spain
Hospital Universitario 12 de Oc
RECRUITING

Madrid, Spain, 28041, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain, 08003, Spain
Istituti Fisioterapici Ospitalieri (IFO)
RECRUITING

Rome, Italy, Italy
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
Keystone Urology Specialists
RECRUITING

Lancaster, Pennsylvania, 17604, United States
Lowcounty Urology Clinics, P.A.
RECRUITING

North Charleston, South Carolina, 29406, United States
MD Anderson Cancer Center - Madrid
RECRUITING

Madrid, 28003, Spain
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Cancer Center - Sidney Kimmel Center for Prostate and Urologic Cancers
RECRUITING

New York, New York, 10065, United States
MidLantic Urology
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
New Jersey Urology, LLC (Summit Health - Washington Township)
RECRUITING

Voorhees Township, New Jersey, 08043, United States
Om Research LLC
RECRUITING

San Diego, California, 92123, United States
Oregon Urology Institute
RECRUITING

Springfield, Ohio, 97477, United States
Specialty Clinical Research of St. Louis
RECRUITING

St Louis, Missouri, 63141, United States
State University of New York (SUNY) Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
The Bronx Veterans Medical Research Foundation, Inc.
RECRUITING

The Bronx, New York, 10468, United States
The James at Brain and Spine Hospital (OSU)
RECRUITING

Columbus, Ohio, 43210, United States
Tri Valley Urology - Murrieta
RECRUITING

Murrieta, California, 92562, United States
University of Kansas Medical Center (KUMC)
RECRUITING

Kansas City, Kansas, 66160, United States
Urology Associates PC
RECRUITING

Nashville, Tennessee, 37209, United States
Urology Austin
RECRUITING

Austin, Texas, 78759, United States
Urology Centers of Alabama
RECRUITING

Homewood, Alabama, 35209, United States
Urology Clinics of North Texas
RECRUITING

Dallas, Texas, 75231, United States
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Urology of Indiana
RECRUITING

Greenwood, Indiana, 46143, United States

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