New hope for Hard-to-Treat cancers: first human trial launches
NCT ID NCT06915753
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 23 times
Summary
This early-phase study tests a new oral drug, TYRA-430, in people with advanced liver cancer or other solid tumors that have specific genetic changes (FGF/FGFR pathway). The main goals are to find the safest dose and check for side effects. About 100 adults will take part. This is a first-in-human trial, so the drug's effectiveness is not yet proven.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSeoul, South Korea
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10043, United States
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John Hopkins University
RECRUITINGBaltimore, Maryland, 21205, United States
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Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
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Mass General Cancer Center
RECRUITINGBoston, Massachusetts, 02114, United States
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National Taiwan University Hospital
RECRUITINGTaipei, Taiwan
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Samsung Medical Center
RECRUITINGSeoul, South Korea
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Sarah Cannon Research Institute Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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Seoul National University Hospital
RECRUITINGSeoul, South Korea
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Severance Hospital, Yonsei University Health System
RECRUITINGSeoul, South Korea
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Stanford Cancer Institute
RECRUITINGStanford, California, 94305, United States
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Taipei Veterans General Hospital
RECRUITINGTaipei, Taiwan
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The University of Kansas Medical Center
RECRUITINGWestwood, Kansas, 66205, United States
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UCSF Medical Center at Mount Zion
RECRUITINGSan Francisco, California, 94158, United States
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USC Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University Health Network Princess Margaret Cancer Center
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Conditions
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