New vaccine-like therapy aims to keep bladder cancer from coming back

NCT ID NCT06833073

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests whether adding an experimental treatment (V940) to standard BCG therapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning. About 308 adults will be randomly assigned to get either V940 plus BCG or BCG alone. The goal is to see if the combination delays cancer growth or recurrence better than BCG alone.

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Conditions

The condition(s) this trial relates to.

bladder carcinoma in situ in situ carcinoma non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms superficial urinary bladder carcinoma urinary bladder neoplasm Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA IN SITU NON-MUSCLE INVASIVE BLADDER NEOPLASMS URINARY BLADDER NEOPLASMS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1000)
RECRUITING

Chaidari/Athens, Attica, 124 62, Greece
Asociación de Beneficencia Hospital Sirio Libanés ( Site 0303)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1419AHN, Argentina
Associated Urological Specialists - Chicago Ridge ( Site 0139)
RECRUITING

Chicago Ridge, Illinois, 60415, United States
Azienda USL 8 di Arezzo ( Site 1203)
RECRUITING

Arezzo, 52100, Italy
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 3002)
RECRUITING

Dusit, Bangkok, 10300, Thailand
Bordeaux University Hospital - Pellegrin ( Site 0806)
RECRUITING

Bordeaux, Gironde, 33076, France
Bradford Hill Norte ( Site 0503)
RECRUITING

Antofagasta, 1240000, Chile
Bradfordhill ( Site 0501)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CHU Dijon Bourgogne ( Site 0802)
RECRUITING

Dijon, Cote-d Or, 21079, France
CHU de Rouen- urology ( Site 0803)
RECRUITING

Rouen, Haute-Normandie, 76031, France
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0204)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0603)
RECRUITING

Bogotá, Bogota D.C., 111321, Colombia
Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k ( Site 1402)
RECRUITING

Poznan, Greater Poland Voivodeship, 61-731, Poland
Clínica Imbanaco S.A.S ( Site 0602)
RECRUITING

Cali, Valle del Cauca Department, Colombia
Debreceni Egyetem Klinikai Kozpont ( Site 1112)
RECRUITING

Debrecen, 4032, Hungary
Erasmus MC ( Site 1300)
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
European Interbalkan Medical Center-Oncology Department ( Site 1008)
RECRUITING

Thessaloniki, 570 01, Greece
FALP ( Site 0500)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Faculty of Medicine - Khon Kaen University ( Site 3001)
RECRUITING

Muang, Changwat Khon Kaen, 40002, Thailand
Fiona Stanley Hospital ( Site 1803)
RECRUITING

Perth, Western Australia, 6150, Australia
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1202)
RECRUITING

Milan, Lombardy, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1200)
RECRUITING

Roma, 00168, Italy
Fundacion Estudios Clinicos ( Site 0304)
RECRUITING

Rosario, Santa Fe Province, S2000DEJ, Argentina
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0301)
RECRUITING

La Rioja, F5300COE, Argentina
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0410)
RECRUITING

São Jose Do Rio Preto, São Paulo, 15090-000, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0400)
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Gartnavel General Hospital ( Site 1702)
RECRUITING

Glasgow, Glasgow City, G12 0YN, United Kingdom
Genesis Healthcare-Torrance ( Site 0140)
RECRUITING

Torrance, California, 90503, United States
Genesis Research LLC ( Site 0118)
RECRUITING

Torrance, California, 90505, United States
Genesis Research, LLC ( Site 0141)
ACTIVE_NOT_RECRUITING

Los Alamitos, California, 90720, United States
Gyor- Moson- Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz ( Site 1116)
RECRUITING

Győr, Győr-Moson-Sopron, 9024, Hungary
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1506)
RECRUITING

Madrid, 28223, Spain
Henry Dunant Hospital ( Site 1005)
RECRUITING

Athens, Attica, 115 26, Greece
Herlev and Gentofte Hospital ( Site 3101)
RECRUITING

Herlev, Capital Region, 2730, Denmark
Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet ( Site 1118)
RECRUITING

Eger, Heves County, 3300, Hungary
Hospital Clinico San Carlos... ( Site 1500)
RECRUITING

Madrid, 28040, Spain
Hospital Insular de Gran Canaria ( Site 1502)
RECRUITING

Las Palmas de Gran Canaria, Canary Islands, 35016, Spain
Hospital Italiano de Buenos Aires ( Site 0307)
RECRUITING

CABA, Buenos Aires, C1199ABD, Argentina
Hospital Militar Central Luis Arias Schereiber ( Site 0700)
RECRUITING

Lima, 15076, Peru
Hospital Universitari Parc Tauli ( Site 1505)
RECRUITING

Sabadell, Barcelona, 08208, Spain
Hospital Universitario 12 de Octubre ( Site 1507)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen Macarena ( Site 1504)
RECRUITING

Seville, 41009, Spain
Hospital de Clínicas de Passo Fundo ( Site 0406)
RECRUITING

Passo Fundo, Rio Grande do Sul, 99010-260, Brazil
Hôpital Foch-Urology department ( Site 0801)
RECRUITING

Suresnes, Hauts-de-Seine, 92150, France
Hôpital Saint-Louis ( Site 0807)
RECRUITING

Paris, Île-de-France Region, 75010, France
IMAT S.A.S ( Site 0601)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0702)
RECRUITING

San Isidro, Lima region, 15038, Peru
Instituto Alexander Fleming ( Site 0306)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Instituto de Cancerología ( Site 0600)
RECRUITING

Medellín, Antioquia, 050021, Colombia
Instituto de Investigaciones Clinicas Mar de Plata ( Site 0305)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Instituto do Câncer e Transplante de Curitiba ( Site 0402)
RECRUITING

Curitiba, Paraná, 80510-130, Brazil
Istituto Nazionale Tumori Regina Elena ( Site 1201)
RECRUITING

Rome, Roma, 00128, Italy
Klinikum Stuttgart - Katharinenhospital ( Site 0909)
RECRUITING

Stuttgart, Baden-Wurttemberg, 70174, Germany
Klinikum der Universität München Großhadern ( Site 0910)
RECRUITING

Munich, Bavaria, 81377, Germany
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0111)
RECRUITING

New York, New York, 10016, United States
Macquarie University ( Site 1801)
RECRUITING

Macquarie University, New South Wales, 2109, Australia
Marienhospital Herne ( Site 0907)
RECRUITING

Herne, North Rhine-Westphalia, 44625, Germany
Metropolitan General Hospital ( Site 1001)
RECRUITING

Athens, Attica, 155 62, Greece
Michael G Oefelein Clinical Trials ( Site 0138)
RECRUITING

Bakersfield, California, 93301, United States
MidLantic Urology ( Site 0102)
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
NHO Revive Research Institute, LLC ( Site 0137)
RECRUITING

Lincoln, Nebraska, 68506, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Moczowego ( Site 1401)
COMPLETED

Warszawa, Lesser Poland Voivodeship, 02-781, Poland
OHSU Knight Cancer Institute - South Waterfront ( Site 0110)
RECRUITING

Portland, Oregon, 97239, United States
ONCOCENTRO APYS ( Site 0505)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Oncocentro Valdivia ( Site 0507)
RECRUITING

Valdivia, Los Ríos Region, 5112129, Chile
Oncosalud ( Site 0701)
RECRUITING

Lima, Lima Province, 15036, Peru
Oncólogos del Occidente S.A.S. - Sede Pereira ( Site 0604)
RECRUITING

Pereira, Risaralda Department, 661001, Colombia
Pontificia Universidad Catolica de Chile ( Site 0502)
RECRUITING

Santiago, Region M. de Santiago, 8330032, Chile
Rijnstate ( Site 1307)
RECRUITING

Arnhem, Gelderland, 6815 AD, Netherlands
Sanatorio Parque ( Site 0300)
RECRUITING

Rosario, Santa Fe Province, S2000DSV, Argentina
Southern Urology, LLC ( Site 0145)
RECRUITING

Lafayette, Louisiana, 70508, United States
St Bartholomew s Hospital ( Site 1700)
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaza ( Site 1117)
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Szegedi Tudomanyegyetem ( Site 1113)
RECRUITING

Szeged, Csongrád megye, 6725, Hungary
Szpital Wojewódzki im. Świętego Lukasza SP ZOZ w Tarnowie ( Site 1404)
RECRUITING

Tarnów, Lesser Poland Voivodeship, 33-100, Poland
Texas Oncology-Austin Central ( Site 0107)
RECRUITING

Austin, Texas, 78705, United States
The Conrad Pearson Clinic ( Site 0143)
RECRUITING

Germantown, Tennessee, 38138, United States
The Moncton Hospital-Oncology ( Site 0200)
RECRUITING

Moncton, New Brunswick, E1C 6Z8, Canada
Torbay Hospital ( Site 1701)
RECRUITING

Torquay, TQ2 7AA, United Kingdom
TriState Urologic Services PSC Inc. dba The Urology Group ( Site 0122)
RECRUITING

Cincinnati, Ohio, 45212, United States
USC Norris Comprehensive Cancer Center ( Site 0123)
RECRUITING

Los Angeles, California, 90033, United States
Universitaetsklinikum Halle ( Site 0902)
RECRUITING

Halle, Saxony-Anhalt, 06120, Germany
Universitaetsklinikum Jena ( Site 0903)
RECRUITING

Jena, Thuringia, 07747, Germany
University of Missouri Health Care ( Site 0126)
RECRUITING

Columbia, Missouri, 65212, United States
University of Washington - Fred Hutchinson Cancer Center ( Site 0100)
RECRUITING

Seattle, Washington, 98195, United States
Urological Research Network ( Site 0133)
RECRUITING

Hialeah, Florida, 33016, United States
Urology Associates ( Site 0144)
RECRUITING

Littleton, Colorado, 80122, United States
Urology Austin, PLLC ( Site 0109)
RECRUITING

Austin, Texas, 78759, United States
Urology of Virginia ( Site 0125)
RECRUITING

Virginia Beach, Virginia, 23462, United States

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