New hope for chronic UTI sufferers: extended antibiotic combo trial launches

NCT ID NCT07202949

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 months will be enrolled. The main goal is to see if this approach reduces bladder inflammation and improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Antibiotics (cefalexin, nitrofurantoin, or trimethoprim) combined with methenamine hippurate
What this could lead to: If successful, this could provide a more effective treatment option for people with chronic UTI, reducing persistent symptoms and improving quality of life.
What could go wrong: This is a mid-stage trial with only 192 participants, so results may not apply to everyone. Antibiotics can cause side effects like gut issues or resistance, and the combination may not work better than current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic cystitis urinary system disorder urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC URINARY TRACT INFECTION

Contacts and locations

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Study contacts

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Locations

Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle upon Tyne, United Kingdom

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St Mary's Hospital, Manchester University NHS Foundation Trust
NOT_YET_RECRUITING

Manchester, United Kingdom

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University College London Hospital (UCLH), UCLH NHS Foundation Trust
RECRUITING

London, United Kingdom

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Whittington Hospital, Whittington Health NHS Trust
RECRUITING

London, United Kingdom

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