New hope for bladder cancer: experimental drug joins standard combo
NCT ID NCT07232602
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding an experimental drug (MK-3120) to the standard treatment (enfortumab vedotin plus pembrolizumab) is safe and effective for people with advanced bladder cancer that has spread. About 55 participants will receive the new combination. Researchers will monitor side effects and measure how many patients' tumors shrink or disappear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-3120 (an investigational drug) given with enfortumab vedotin and pembrolizumab
What this could lead to
If it works, this could lead to a more effective first-line treatment for advanced bladder cancer, potentially shrinking tumors in more patients.
What could go wrong
This is an early phase 1/2 trial with only 55 participants, so results may not apply to everyone. Adding a new drug to standard therapy also raises unknown safety risks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center ( Site 5901)
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-••••
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CHU de Bordeaux Hop St ANDRE ( Site 5607)
RECRUITINGBordeaux, Gironde, 33075, France
Contact Phone: •••-•••-••••
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Cleveland Clinic Taussig Cancer ( Site 5036)
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-••••
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Erasmus MC ( Site 5303)
RECRUITINGRotterdam, South Holland, 3015 GD, Netherlands
Contact Phone: •••-•••-••••
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FALP ( Site 5151)
RECRUITINGSantiago, Region M. de Santiago, 7500921, Chile
Contact Phone: •••-•••-••••
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Hospital Clinico San Carlos ( Site 5765)
RECRUITINGMadrid, 28040, Spain
Contact Phone: •••-•••-••••
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Hospital Universitari Vall de Hebron ( Site 5767)
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-••••
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Huntsman Cancer Institute ( Site 5041)
RECRUITINGSalt Lake City, Utah, 84112-5550, United States
Contact Phone: •••-•••-••••
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Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL) ( Site 5302)
RECRUITINGAmsterdam, North Holland, 1066 CX, Netherlands
Contact Phone: •••-•••-••••
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Rabin Medical Center ( Site 5504)
RECRUITINGPetah Tikva, 4941492, Israel
Contact Phone: •••-•••-••••
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Rambam Health Care Campus ( Site 5501)
RECRUITINGHaifa, 3109601, Israel
Contact Phone: •••-•••-••••
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Samsung Medical Center ( Site 5902)
RECRUITINGSeoul, 06351, South Korea
Contact Phone: •••-•••-••••
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Severance Hospital, Yonsei University Health System ( Site 5903)
RECRUITINGSeoul, 03722, South Korea
Contact Phone: •••-•••-••••
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St Bartholomew s Hospital ( Site 5206)
RECRUITINGLondon, London, City of, EC1A 7BE, United Kingdom
Contact Phone: •••-•••-••••
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UCSF Medical Center at Mission Bay ( Site 5044)
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-••••
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University of Chicago Medical Center ( Site 5037)
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-••••