New radioactive 'Smart Bomb' targets Hard-to-Treat lung cancer
NCT ID NCT07278479
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug that delivers radiation directly to cancer cells carrying a protein called DLL3, found in small cell lung cancer and other solid tumors. The trial enrolls 138 adults whose cancer has progressed after at least two prior treatments. The goal is to check safety, find the right dose, and see if the drug can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A radioactive drug that targets DLL3 on cancer cells
- What this could lead to
- If it works, this could provide a new treatment option for people with advanced small cell lung cancer that has stopped responding to standard therapies.
- What could go wrong
- This is an early-phase trial (phase 1/2a) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Radiation-based drugs can cause side effects like damage to healthy tissues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Emory University Hospital
RECRUITINGAtlanta, Georgia, 30322, United States
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Nebraska Cancer Specialists
RECRUITINGOmaha, Nebraska, 68130, United States
Contact Email: •••••@•••••
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United Theranostics
RECRUITINGGlen Burnie, Maryland, 21061, United States
Contact Email: •••••@•••••
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United Theranostics
RECRUITINGPrinceton, New Jersey, 08540, United States
Contact Email: •••••@•••••
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
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