Bladder cancer combo trial: could adding chemo to BCG keep tumors away?

NCT ID NCT07000084

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether adding the chemotherapy drug gemcitabine to standard BCG therapy can better prevent high-grade bladder cancer from coming back. About 330 people with recurrent non-muscle invasive bladder cancer will receive either BCG alone or BCG plus gemcitabine, both given directly into the bladder. The main goal is to see how long participants stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gemcitabine (chemotherapy) and BCG (immune-stimulating bacteria solution)
What this could lead to: If it works, this could offer a more effective treatment option for people with recurrent high-grade bladder cancer, potentially reducing the chance of the cancer coming back.
What could go wrong: This is a phase 3 trial, but it's still experimental. Adding gemcitabine may increase side effects, and it's not yet known if it will be better than BCG alone. Results may not apply to all bladder cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms superficial urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT NON-MUSCLE INVASIVE BLADDER CARCINOMA STAGE 0A BLADDER CANCER AJCC V8 STAGE I BLADDER CANCER AJCC V8

Contacts and locations

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Locations

Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Benefis Helena Specialty Center
RECRUITING

Helena, Montana, 59601, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Billings Clinic-Cody
RECRUITING

Cody, Wyoming, 82414, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
FMH James M Stockman Cancer Institute
RECRUITING

Frederick, Maryland, 21702, United States
Fairbanks Memorial Hospital
RECRUITING

Fairbanks, Alaska, 99701, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fox Chase Cancer Center-Rockledge
RECRUITING

Rockledge, Pennsylvania, 19046, United States
Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

Contact Email: •••••@•••••
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Great Falls Clinic
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hi-Line Sletten Cancer Center
RECRUITING

Havre, Montana, 59501, United States
IU Health Methodist Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Email: •••••@•••••
IU Health North Hospital
RECRUITING

Carmel, Indiana, 46032, United States

Contact Email: •••••@•••••
IU Health West Hospital
RECRUITING

Avon, Indiana, 46123, United States

Contact Email: •••••@•••••
Indiana University/Melvin and Bren Simon Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States

Contact Email: •••••@•••••
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lahey Clinic
RECRUITING

Burlington, Massachusetts, 01805, United States
Lahey Clinic Peabody
RECRUITING

Peabody, Massachusetts, 01960, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
RECRUITING

Melrose Park, Illinois, 60160, United States
Mary Bird Perkins Cancer Center - Metairie
RECRUITING

Metairie, Louisiana, 70002, United States
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hospital of Laramie County
RECRUITING

Cheyenne, Wyoming, 82001, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Ralph H Johnson VA Medical Center
RECRUITING

Charleston, South Carolina, 29401, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States
University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

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