New bladder cancer drug shows promise in early trial

NCT ID NCT07206225

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests a new drug called PF-08052667 for adults with a type of bladder cancer that hasn't spread into the muscle layer but is likely to return. The drug is given directly into the bladder, sometimes with other medicines like BCG or sasanlimab. The trial has three parts to find the best dose and see how safe and effective the drug is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08052667 (a drug given directly into the bladder)
What this could lead to: If it works, this could offer a new treatment option for people with bladder cancer that hasn't responded to standard therapies.
What could go wrong: This is an early Phase 1 trial focused on safety and dosing, so it's too soon to know if the drug will be effective. Side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bladder carcinoma in situ bladder papillary urothelial carcinoma non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-MUSCLE INVASIVE BLADDER CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

64th Street Outpatient and Innovation Center
NOT_YET_RECRUITING

New York, New York, 10065, United States
AUC Urologists, LLC
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Baptist M&S Imaging (Medical Center)
RECRUITING

San Antonio, Texas, 78229, United States
Biorepository and Precision Pathology Center (BRPC)
RECRUITING

Durham, North Carolina, 27710, United States
Cancer Center Outpatient Building
RECRUITING

Dallas, Texas, 75235, United States
Carolina Urologic Research Center, LLC
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Coastal Eye Group
RECRUITING

Myrtle Beach, South Carolina, 29579, United States
Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Grand Strand Medical Center
RECRUITING

Myrtle Beach, South Carolina, 295724607, United States
Gustave Roussy
RECRUITING

Villejuif, VAL DE Marne, 94800, France
Hadassah Medical Center
RECRUITING

Jerusalem, Jerusalem, 9112001, Israel
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
MCOA Eye Associates
RECRUITING

San Antonio, Texas, 78240, United States
MSK Basking Ridge
NOT_YET_RECRUITING

Basking Ridge, New Jersey, 07920, United States
MSK Bergen
NOT_YET_RECRUITING

Montvale, New Jersey, 07645, United States
MSK Commack
NOT_YET_RECRUITING

Commack, New York, 11725, United States
MSK Monmouth
NOT_YET_RECRUITING

Middletown, New Jersey, 07748, United States
MSK Nassau
NOT_YET_RECRUITING

Uniondale, New York, 11553, United States
MSK Westchester
NOT_YET_RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
NOT_YET_RECRUITING

New York, New York, 10021, United States
Memorial Sloan Kettering Cancer Center - Main Campus
NOT_YET_RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Cancer Center 53rd street
NOT_YET_RECRUITING

New York, New York, 10022, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Moffitt Cancer Center - International Plaza
RECRUITING

Tampa, Florida, 33607, United States
Moffitt Cancer Center - McKinley Campus
RECRUITING

Tampa, Florida, 33612, United States
Moffitt Cancer Center at SouthShore
RECRUITING

Ruskin, Florida, 33570, United States
Moffitt Cancer Center at Wesley Chapel
RECRUITING

Wesley Chapel, Florida, 33544, United States
Moffitt McKinley Hospital
RECRUITING

Tampa, Florida, 33612, United States
Northwestern Memorial Hospital
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Northwestern University - Feinberg School of Medicine
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Parkway Surgery Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Pitie Salpetriere University Hospital
RECRUITING

Paris, 75013, France
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Rambam Health Care Campus
NOT_YET_RECRUITING

Haifa, Northern District, 3109601, Israel
Royal Hallamshire Hospital
RECRUITING

Sheffield, South Yorkshire, S10 2JF, United Kingdom
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
SUNY Upstate Medical University-Community Campus
RECRUITING

Syracuse, New York, 13215, United States
Samsung Medical Center
RECRUITING

Seoul, Seoul Teukbyeolsi [seoul], 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi, 03722, South Korea
Sheba Medical Center
RECRUITING

Ramat Gan, Central District, 5265601, Israel
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, England, S10 2SJ, United Kingdom
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING

New York, New York, 10065, United States
Substrate Services Core Research Support (SSCRS)
RECRUITING

Durham, North Carolina, 27710, United States
The Kirklin Clinic of UAB Hospital
RECRUITING

Birmingham, Alabama, 35233, United States
The University of Alabama at Birmingham Investigation Drug Services Pharmacy
RECRUITING

Birmingham, Alabama, 35249, United States
The University of Kansas - Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
The University of Kansas Cancer Center - Westwood
RECRUITING

Westwood, Kansas, 66205, United States
The University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States
The University of Kansas Hospital - Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
The University of Kansas Hospital Cambridge North Tower A
RECRUITING

Kansas City, Kansas, 66160, United States
The University of Kansas Medical Center Medical Office Building
RECRUITING

Kansas City, Kansas, 66160, United States
The University of Sheffield
RECRUITING

Sheffield, S10 2RX, United Kingdom
The University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
UAB Infusion Therapy Extended Care Clinic (ECC)
RECRUITING

Birmingham, Alabama, 35233, United States
USA Clinical Trials
RECRUITING

San Antonio, Texas, 78229, United States
UT Southwestern Medical Center - West Campus Building
RECRUITING

Dallas, Texas, 75390, United States
UT Southwestern Medical Center - William P Clements Jr University Hospital
RECRUITING

Dallas, Texas, 75390, United States
UT Southwestern Medical Center-William P. Clements Imaging Center
RECRUITING

Dallas, Texas, 75390, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
Upstate Specialty Services at Harrison Center
RECRUITING

Syracuse, New York, 13202, United States
Urology Associates, P.C.
RECRUITING

Nashville, Tennessee, 37209, United States
Weston Park Cancer Centre
RECRUITING

Sheffield, S10 2SJ, United Kingdom

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