New radioactive 'Smart Bomb' targets Hard-to-Treat cancers

NCT ID NCT05706129

Recruiting now Disease control Sponsor: Lumara Bio Oncologics GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study is testing a new way to find and treat several types of advanced solid tumors, including kidney, pancreatic, and colorectal cancers. It uses a special radioactive compound that attaches to a protein found on these cancer cells. The study has multiple parts: first, to see if the imaging agent is safe and can spot tumors; then, to find the best dose of the treatment version; and finally, to check if the treatment shrinks tumors. About 270 adults with cancers that have spread or cannot be removed by surgery will take part.

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Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma colorectal cancer colorectal neoplasm head and neck cancer Head and Neck Neoplasms infiltrating bladder urothelial carcinoma non-small cell squamous lung carcinoma nonpapillary renal cell carcinoma pancreatic ductal adenocarcinoma renal cell carcinoma transitional cell carcinoma triple-negative breast carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL RENAL CELL CANCER (CCRCC) COLORECTAL CANCER (CRC) HEAD AND NECK CANCER (H&N) INDETERMINATE RENAL MASS (IDRM) MUSCLE INVASIVE BLADDER CANCER (MIBC) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) SQUAMOUS NON-SMALL CELL LUNG CANCER (NSCLC) TRIPLE-NEGATIVE BREAST CANCER (TNBC) UROTHELIAL CARCINOMA (UC)

Contacts and locations

Locations

AP-HM - Hopital de la Timone
RECRUITING

Marseille, 13005, France
CHRU de Nancy - Hopitaux de Brabois
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
CHU de Grenoble-Alpes, Boulevard de la Chantourne
RECRUITING

Grenoble, 38043, France
CHU de Nantes
RECRUITING

Nantes, 44093, France
Centre Georges François Leclerc
RECRUITING

Dijon, 21079, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, 63011, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
IUCT - Oncopole
RECRUITING

Toulouse, 31100, France
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, VIC 3000, Australia
UNSW Sydney, St Vincent's Hospital Sydney
RECRUITING

Sydney, NSW 2010, Australia

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