COLORECTAL CANCER (CRC)

This study tests whether combining experimental RAS(ON) inhibitors with ivonescimab (an immunotherapy) can shrink or control advanced solid tumors that have a RAS mutation. About 370 adults with cancers like non-small cell lung cancer or colorectal cancer will receive these drugs…

This study tests a new drug called zanzalintinib, alone or with other immune-boosting drugs, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find safe doses and see if the combination can shrink tumors or slow their growth.…

This study tests a combination of two drugs (fruquintinib and FOLFIRI) in people with advanced colorectal cancer that has spread. It is for those who have already had one prior treatment. The goal is to see if this new combination can help control the cancer longer and with manag…

This early-phase study tests an experimental drug called OKN4395, taken as a pill, alone or together with the immunotherapy pembrolizumab. The goal is to find a safe dose and see if the combination can shrink tumors in people with advanced solid cancers like lung, colorectal, sto…

This early-phase trial tests a new drug called CBI-1214 in 80 people with advanced colorectal cancer that has not responded to standard treatments. CBI-1214 is designed to connect the body's own immune T cells to cancer cells, helping the immune system attack the tumor. The main …

This phase 2 trial is testing whether combining the drug pirfenidone with an immunotherapy (PD-1 inhibitor), and possibly adding focused radiation, can help people with advanced colorectal cancer that hasn't responded to standard treatments. The study will enroll 48 adults aged 1…

This early-stage trial tests a new drug called KO-2806, alone or with other cancer drugs, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and check for early signs of tumor shrinkage. About 300 participants wi…

This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried stan…

This study tests an experimental drug called RMC-9805, taken as a pill, in adults with advanced solid tumors (such as lung, colorectal, or pancreatic cancer) that have a specific mutation in the KRAS gene called G12D. The drug is given alone or in combination with another oral dr…

This study tests a new drug called BMS-986523, alone or with other cancer drugs, in people with advanced solid tumors (like lung, colorectal, or pancreatic cancer) that have a specific genetic change (KRAS mutation). The goal is to see if it is safe and works. About 252 adults wi…

This program offers early access to a combination of two immunotherapy drugs, botensilimab and balstilimab, for people with serious or life-threatening cancers like colorectal, pancreatic, lung, liver, melanoma, sarcoma, ovarian, or prostate cancer. It is for patients who have tr…

This study is testing an experimental oral drug called RMC-6236 in adults with advanced solid tumors (like lung, colorectal, or pancreatic cancer) that have specific RAS mutations. The main goals are to find safe doses and understand side effects. About 754 participants will take…

This study tests a new approach for people with a common type of locally advanced rectal cancer. It combines low-dose radiation with an immunotherapy drug (pucotenlimab) and chemotherapy before surgery. The goal is to see if this combination can make the tumor disappear completel…

This study is for people with stage I or low-risk stage II colorectal cancer who have a positive ctDNA blood test one month after surgery, indicating a higher risk of recurrence. Researchers will assign different chemotherapy regimens based on ctDNA results to see if this persona…

This study tests a new drug, tegavivint, in people with metastatic colorectal cancer that has worsened after at least two prior treatments. The trial aims to find a safe dose and see if the drug shrinks tumors when used alone or with standard therapies. About 126 adults with spec…

This study tests a new oral drug called JYP0015 in people with advanced solid tumors (such as pancreatic, lung, or colorectal cancer) that have a RAS mutation. The drug aims to block the activity of the mutated RAS protein, which drives cancer growth. The trial will enroll 210 pa…

This early-phase trial is testing an experimental drug called TH9619 in about 43 adults with advanced solid tumors, including colorectal, head and neck, lung, and gastric cancers. The main goal is to check the drug's safety and find the right dose. Participants must have already …

This study tests whether adding two drugs (bevacizumab and a PD-1 inhibitor) to standard chemotherapy before surgery can improve outcomes for people with a common, hard-to-treat type of colorectal cancer. About 166 adults with locally advanced pMMR/MSS colorectal cancer will be r…

This study is testing a new drug called ABT-301 combined with two other drugs (tislelizumab and bevacizumab) in people with advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if the combination is safe and can shrink tumors. Abo…

This study tests a new drug called HLX43 in 60 people with advanced colorectal cancer that has stopped responding to standard treatments. The drug is designed to attach to a protein on cancer cells and deliver a toxin to kill them. The main goal is to find the right dose and see …

This study is testing a new way to find and treat several types of advanced solid tumors, including kidney, pancreatic, and colorectal cancers. It uses a special radioactive compound that attaches to a protein found on these cancer cells. The study has multiple parts: first, to s…

This early-phase study is testing two radioactive imaging agents, 68Ga-DFC413 and 68Ga-NNS309, to see how well they highlight tumors on PET scans. About 66 adults with advanced pancreatic, lung, breast, colorectal, or soft tissue cancers will receive the agents. The goal is to co…

This study will test whether artificial intelligence (AI) can help doctors find and identify colorectal polyps during colonoscopy better than standard methods. About 1000 adults having a routine colonoscopy will be randomly assigned to either AI-assisted or standard colonoscopy. …

This study is looking at whether analyzing the bacteria in a person's stool can help detect colorectal cancer earlier, especially in people under 50 who are not routinely screened. Researchers will collect stool samples and diet information from 400 adults in Portugal recently di…

This study is testing whether a quick, at-home stool test (FIT) can accurately detect if bowel cancer has returned after surgery. About 1,000 patients who are due for a routine colonoscopy will also provide a FIT sample. If the test works well, some patients might be able to skip…

This study is testing whether a tiny camera in a pill (colon capsule endoscopy) can find colorectal cancer or precancerous growths in people who have had a bloodstream infection with certain gut bacteria. About 100 adults will swallow the camera 4-8 weeks after leaving the hospit…

This study is testing a blood test that looks for DNA fragments to detect colorectal cancer and advanced adenomas. Researchers will collect blood samples from 1,300 people in the U.S., including those with suspected cancer or adenomas and those undergoing routine screening. The g…

This study is testing a new blood test called Delta-HLD to see how well it can detect colorectal cancer in average-risk people aged 45-75. About 3,200 participants will give a blood sample before their scheduled screening colonoscopy, which will be used as the gold standard for c…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will use an acti…

This study aims to improve early detection of colorectal cancer by analyzing gut bacteria in stool samples from 30,000 people in Portugal aged 40-74. Researchers will compare the microbiome of healthy individuals with those who have precancerous polyps or cancer, looking for uniq…

This study aims to understand why liver metastases are so deadly in colorectal and pancreatic cancers. Researchers will analyze tumors and blood from 625 participants to find new targets for immune and gene therapies. The goal is to develop better treatments for these hard-to-tre…

This study looks at whether proteins in urine can help doctors predict how patients with advanced colorectal cancer will respond to treatment given before surgery. Researchers will collect urine samples from 400 participants before and after therapy and use advanced technology to…

This study looks at how the type of anesthesia used during colorectal cancer surgery affects muscle loss and strength after the operation. Researchers will measure muscle size and function using ultrasound, grip strength tests, and body composition scans. The goal is to find out …