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New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT06026410

Recruiting now Disease control Sponsor: Kura Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage trial tests a new drug called KO-2806, alone or with other cancer drugs, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and check for early signs of tumor shrinkage. About 300 participants will be enrolled across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
KO-2806 (darlifarnib), cabozantinib, adagrasib
What this could lead to
If successful, this could point toward a new treatment option for certain advanced solid tumors that have not responded to standard therapies.
What could go wrong
This is an early Phase 1 trial, so safety and effectiveness are not yet established. Many drugs fail at this stage, and side effects may be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm kidney cancer neoplasm non-small cell lung carcinoma nonpapillary renal cell carcinoma pancreatic ductal adenocarcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEAR CELL RENAL CELL CARCINOMA (CCRCC) COLORECTAL CANCER (CRC) NON-CLEAR CELL RENAL CELL CARCINOMA (NCCRCC) NON-SMALL CELL LUNG CANCER (NSCLC) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) RENAL CELL CARCINOMA (KIDNEY CANCER) SOLID TUMORS WITH HRAS ALTERATIONS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AOU Verona - Centro Ricerche Cliniche di Verona

    RECRUITING

    Verona, 37134, Italy

  • AdventHealth Celebration

    RECRUITING

    Celebration, Florida, 34747, United States

  • Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS

    RECRUITING

    Bologna, 40138, Italy

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Centre Leon Berard

    RECRUITING

    Lyon, 69495, France

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, 12203, Germany

  • Dana-Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Florida Cancer Specialists

    RECRUITING

    Sarasota, Florida, 34232, United States

  • Fondazione Piemonte per l'Oncologia - IRCCs Candiolo

    RECRUITING

    Candiolo, 10060, Italy

  • Henry Ford Health System

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hopital Européen Georges Pompidou

    RECRUITING

    Paris, 75015, France

  • Hospital HM Sanchinarro START Madrid-CIOCC

    RECRUITING

    Madrid, 28050, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen del Rocío

    RECRUITING

    Seville, 41013, Spain

  • Hospital de la Santa Creu i de Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Humanitas University

    RECRUITING

    Rozzano, 20089, Italy

  • Institut Universitaire du Cancer Toulouse - Oncopole

    RECRUITING

    Toulouse, 31059, France

  • Istituto Nazionale Tumori IRCCS

    RECRUITING

    Naples, 80131, Italy

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Mayo Clinic Comprehensive Cancer Center

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Comprehensive Cancer Center

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Comprehensive Cancer Center

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • OU Stephenson Cancer Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Oncologie médicale - Pitié-Salpêtrière

    RECRUITING

    Paris, 75013, France

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • SCRI - Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Sarah Cannon Research Institute at HealthONE

    RECRUITING

    Denver, Colorado, 80218, United States

  • UCLA Department of Medicine

    RECRUITING

    Los Angeles, California, 90095, United States

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • UT Southwestern Simmons Cancer Center

    RECRUITING

    Dallas, Texas, 75235, United States

  • University of Arizona

    RECRUITING

    Tucson, Arizona, 85724, United States

  • University of Iowa Hospitals & Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Southern California

    RECRUITING

    Los Angeles, California, 90033, United States

  • University of Wisconsin (Carbone Cancer Center)

    RECRUITING

    Madison, Wisconsin, 53792, United States

    Contact Email: •••••@•••••

  • Universitätsklinikum Ulm

    RECRUITING

    Ulm, 89081, Germany

  • Universitätsklinikum Würzburg

    RECRUITING

    Würzburg, 97080, Germany

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.