New hope for advanced cancers? first human trial of TH9619 begins
NCT ID NCT07151040
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing an experimental drug called TH9619 in about 43 adults with advanced solid tumors, including colorectal, head and neck, lung, and gastric cancers. The main goal is to check the drug's safety and find the right dose. Participants must have already tried at least one standard chemotherapy. The study is open-label, meaning everyone knows they are getting the drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TH9619 (an experimental drug)
- What this could lead to
- If this trial succeeds, it could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This is a very early, first-in-human study with only 43 participants. The drug may not be safe or effective, and side effects are unknown. Many early-stage cancer drugs fail to advance.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Universitario Fundacion Jimenez Diaz
RECRUITINGMadrid, Spain
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Institut Gustave Roussy
RECRUITINGVillejuif, France
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Newcastle University
RECRUITINGNewcastle upon Tyne, United Kingdom
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Vall D Hebron Institute Of Oncology
RECRUITINGBarcelona, Spain
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