COLORECTAL CANCER (CRC)
Clinical trials for COLORECTAL CANCER (CRC) explained in plain language.
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New antibody combo tested against hard-to-treat cancers
Disease control OngoingThis early-phase trial tests an experimental antibody called GEN1042, given alone or with the cancer drug pembrolizumab (and sometimes chemotherapy), in people with advanced solid tumors like lung, colon, melanoma, head and neck, or pancreatic cancer. The main goals are to check …
Matched conditions: COLORECTAL CANCER (CRC)
Phase: PHASE1, PHASE2 • Sponsor: Genmab • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Promising cancer therapy study pulled before it began
Disease control TerminatedThis study aimed to test a new treatment called CAR-T cell therapy for people with advanced colorectal cancer. The therapy uses specially modified immune cells to target two proteins on cancer cells. However, the study was withdrawn before any participants were enrolled, so no re…
Matched conditions: COLORECTAL CANCER (CRC)
Phase: NA • Sponsor: Guangzhou Bio-gene Technology Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:39 UTC
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New pill targets Hard-to-Treat cancers in early trial
Disease control OngoingThis early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…
Matched conditions: COLORECTAL CANCER (CRC)
Phase: PHASE1 • Sponsor: Revolution Medicines, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could a lower dose of immunotherapy shrink colorectal tumors before surgery?
Disease control OngoingThis phase 2 trial is testing whether low doses of the immunotherapy drugs nivolumab or pembrolizumab can shrink tumors in people with a specific genetic type of colorectal cancer (MSI/dMMR) before they have surgery. The study involves 30 participants with stage II-III disease wh…
Matched conditions: COLORECTAL CANCER (CRC)
Phase: PHASE2 • Sponsor: Blokhin's Russian Cancer Research Center • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Cancer drug ruxolitinib keeps flowing to stable patients in rollover trial
Disease control OngoingThis study offers continued access to the cancer drug ruxolitinib (sometimes combined with other therapies) for people with pancreatic, colorectal, breast, or lung cancer who were already benefiting and stable in a prior Incyte-sponsored trial. Only 10 participants are enrolled, …
Matched conditions: COLORECTAL CANCER (CRC)
Phase: PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Mailed cancer tests battle: which stool test screens better for colon cancer?
Diagnosis ENROLLING_BY_INVITATIONThis study compares two mailed stool tests—Cologuard and FIT—for colorectal cancer screening in adults aged 45-49 who are not up to date with screening. Researchers will measure how many people complete screening and follow up on abnormal results. The goal is to find the most eff…
Matched conditions: COLORECTAL CANCER (CRC)
Phase: NA • Sponsor: University of California, San Diego • Aim: Diagnosis
Last updated Jun 26, 2026 14:30 UTC
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Blood test may boost colorectal cancer screening in underserved communities
Knowledge-focused OngoingThis study tests whether offering a blood test (cell free DNA) alongside standard stool tests and colonoscopy increases colorectal cancer screening rates among people who are not up-to-date with screening. The trial enrolls 340 adults aged 45-75 at a health center serving low-inc…
Matched conditions: COLORECTAL CANCER (CRC)
Phase: NA • Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Robot surgery may cut complications in colorectal cancer operations
Knowledge-focused OngoingThis study looks back at data from 128,000 colorectal cancer patients in Germany to compare robot-assisted surgery with standard laparoscopic surgery. The goal is to see if robot-assisted surgery leads to fewer conversions to open surgery, fewer complications, and better long-ter…
Matched conditions: COLORECTAL CANCER (CRC)
Sponsor: Medizinische Hochschule Brandenburg Theodor Fontane • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:35 UTC