COLORECTAL CANCER (CRC)

This early-phase study tests an experimental drug called RMC-6291 in adults with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to find a safe dose and see how the body processes the drug. About 222 people with lung, colorectal, or pancreatic cancer th…

This study tests a low-dose immunotherapy drug (nivolumab or pembrolizumab) in 30 people with a specific type of advanced colorectal cancer (MSI/dMMR). The goal is to see if the treatment can shrink or eliminate the tumor before surgery. Participants receive the drug for 6 months…

This study offers continued treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte-sponsored trial. Participants must have stable disease and be tolerat…

This study tests an experimental antibody called GEN1042, alone or with the cancer drug pembrolizumab (with or without chemotherapy), in people with advanced solid tumors like lung, colon, melanoma, head and neck, or pancreatic cancer. The goal is to see if the treatment is safe …

This study compares two at-home stool tests—Cologuard and FIT—sent by mail to adults ages 45-49 who are due for colorectal cancer screening. The goal is to see which test leads to more people completing screening. About 400 participants from the UCSD Health system will take part.…

This study looks back at data from 128,000 people in Germany who had surgery for colorectal cancer. It compares robot-assisted surgery to standard laparoscopic (keyhole) surgery to see which one leads to fewer problems and better long-term survival. The goal is to find out if usi…