New pill targets Hard-to-Treat cancers in early trial
NCT ID NCT05462717
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, and researchers will monitor side effects and drug levels in the blood.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ajou University Hospital
Suwon, Gyeonggi-do, 16499, South Korea
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American Oncology Partners of Maryland
Bethesda, Maryland, 20817, United States
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Austin Health, Olivia Newton-John Cancer Research & Wellness Centre
Heidelberg, Victoria, 3084, Australia
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Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, 10043, Italy
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CHU Bordeaux Hospital Saint-Andre
Bordeaux, 33000, France
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CHU Nantes
Nantes, 44093, France
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Centre Jean Perrin
Clermont-Ferrand, 63011, France
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Centre Léon Bérard
Lyon, 69008, France
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Centre Oscar Lambret
Lille, 59000, France
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Centro Ricerche Cliniche di Verona s.r.l.
Verona, 37134, Italy
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Chiang Mai University
Chiang Mai, 50200, Thailand
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Clinica Universidad de Navarra
Pamplona, 31008, Spain
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Clinical hospital center Bezanijska Kosa
Belgrade, 11071, Serbia
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Clínica Universidad de Navarra
Madrid, 28027, Spain
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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E-DA hospital
Kaohsiung City, Yanchao District, 82445, Taiwan
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Highlands Oncology Group
Springdale, Arkansas, 72762, United States
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Hospital Universitario Fundación Jiménez Díaz
Madrid, 28040, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Quirónsalud
Pozuelo de Alarcón, 28223, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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ICANS
Strasbourg, 67200, France
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ICO
Angers, 49055, France
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ICO Hospitalet
Barcelona, 08908, Spain
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Institute for pulmonary diseases Sremska Kamenica
Kamenitz, 21204, Serbia
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Instytut MSF Sp zoo
Lodz, 90-302, Poland
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Istituto Europeo Oncologico
Milan, 20141, Italy
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Istituto Nazionale Tumori Fondazione G. Pascale
Naples, 80131, Italy
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Khon Kaen University
Khon Kaen, 40002, Thailand
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Klinika onkologie a radioterapie, Fakultni Nemocnice Hradec Kralove
Hradec Králové, 50005, Czechia
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Korea University Hospital
Seoul, 02708, South Korea
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MD Anderson Cancer Center
Madrid, 28033, Spain
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MSB General Hospital
Belgrade, 11000, Serbia
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MSK Cancer Center
New York, New York, 10021, United States
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Med - Polonia Sp. z o. o.
Poznan, 60-693, Poland
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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NEXT Oncology IOB Hospital Quirónsalud
Barcelona, 08023, Spain
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NH Hospital a.s.
Hořovice, 268 31, Czechia
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Narodowy Instytut Onkologii
Warsaw, 02-781, Poland
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National Cancer centre Singapore
Singapore, 168583, Singapore
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National Cheng Kung University Hospital
Tainan, 70457, Taiwan
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National Taiwan University Hospital
Taipei, 10048, Taiwan
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Next Oncology
San Antonio, Texas, 78229, United States
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Next Oncology Virginia
Fairfax, Virginia, 22031, United States
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Onkologicka klinika, Fakultni Nemocnice Olomouc
Olomouc, 77900, Czechia
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Peninsula & South Eastern Haematology and Oncology Group
Frankston, Victoria, 3199, Australia
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14203, United States
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S.C. Oncologia Falck, Dipartimento Ematologia ed Oncologia Niguarda Cancer Center
Milan, 20162, Italy
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START
San Antonio, Texas, 78229, United States
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Sarawak General Hospital
Kuching, 93586, Malaysia
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Seoul National University Hospital
Seoul, 3080, South Korea
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Severance Hospital
Seoul, 3722, South Korea
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Siriraj Hospital
Bangkok Noi, 10700, Thailand
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South West Health Care
Warrnambool, Victoria, 3280, Australia
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Southside Cancer Care Centre
Sydney, New South Wales, 2228, Australia
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Taipei Tzu Chi Hospital
New Taipei City, 231, Taiwan
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Tennessee Oncology
Nashville, Tennessee, 37203, United States
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UC Davis Cancer Center
Sacramento, California, 95817, United States
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UC Irvine Cancer Center
Orange, California, 92868, United States
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UCSF
San Francisco, California, 94158, United States
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University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
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University of Miami School of Medicine Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can pancreatic Cancer's inflammatory footprint be stopped?
- Can your own immune cells beat advanced cancer?
- Blood and gut clues may flag pancreatic cancer risk early
- Why are more younger adults getting colorectal cancer? a national study digs into the data
- Tumor DNA mapping may unlock personalized cancer therapies
- Can a new drug combo shrink Hard-to-Treat tumors?