COLORECTAL CANCER (CRC)

This study tests a new drug called BPI-572270 in 120 adults with advanced solid tumors (lung, colon, or pancreatic cancer) that have specific RAS gene mutations. The goal is to see if the drug is safe and can shrink or control the tumors. Participants must have already tried stan…

This study tests whether adding lubiprostone, a drug used for constipation, to standard maintenance therapy can delay cancer recurrence in 124 adults with colorectal cancer that has spread to the lining of the abdomen. Participants have already had surgery to remove visible tumor…

This study tests if a new drug called IP-001, injected into the liver after standard heat ablation, can prevent colorectal cancer from coming back in people whose cancer has spread only to the liver. About 717 adults will be randomly assigned to receive ablation alone or ablation…

This early-phase study tests a new daily pill, KQB368, in adults with advanced solid tumors (like lung, colon, or uterine cancer) that have a KRAS G12S or G12C mutation and no standard cure. The main goals are to find a safe dose and see if the drug can shrink tumors. About 48 pa…

This study works with American Indian communities to help more people get a colonoscopy after a positive screening test. Colorectal cancer kills many American Indians, and this project tests a program to make sure patients get the follow-up test within 60 days. About 446 adults a…

This study tests a non-invasive electrical stimulation device (TEA) placed on the skin to help elderly patients (65+) recover bowel function faster after colorectal cancer surgery. Participants receive either real TEA or a sham treatment twice daily for three days after surgery. …

This study looks at whether taking magnesium by mouth and soaking feet in a magnesium solution can reduce nerve damage (tingling, numbness) and improve sleep in people with colorectal cancer getting chemotherapy. About 75 adults will be split into three groups: one gets oral magn…