COLORECTAL CANCER (CRC)

This study tests a new approach for people with a common type of locally advanced rectal cancer. Participants receive a single low dose of radiation, followed by a combination of an immunotherapy drug (pucotenlimab) and chemotherapy (CAPEOX) before surgery. The goal is to see if …

This early-stage study tests a new drug called XL092, alone or with other immune-boosting drugs, in people with advanced solid tumors (like kidney, prostate, lung, or colon cancer) that can't be removed by surgery. The main goals are to find safe doses and see if the treatment sh…

This study tests a new treatment called CAR-T cell therapy for people with advanced colorectal cancer that has not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target two proteins (CDH17 and GUCY2C) found on cancer cells. The goal i…

This study tests a new combination of drugs (RAS(ON) inhibitors plus ivonescimab) in adults with advanced or metastatic solid tumors that have a RAS mutation. The goal is to see if the combination is safe and can shrink tumors or slow their growth. About 370 people with cancers l…

This early-stage study tests a new drug called RMC-5127 in adults with advanced solid tumors that have a specific KRAS G12V gene change. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 574 people with lung, colorectal, or panc…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by helping the body's immune cells attack cancer cells. The main goals are to check safety and find the best dose, while…

This early-stage study tests a new drug called KO-2806 in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and see if the drug can shrink tumors, either alone or combined with other therapies. About 300 adults wi…

This study tests a new drug called HLX43 in 60 adults with advanced colorectal cancer that has stopped responding to standard treatments. The drug is designed to target and kill cancer cells while sparing healthy ones. The main goal is to find the best dose and see if it shrinks …

This study tests whether adding a PD-1 immunotherapy drug to standard chemotherapy and bevacizumab can improve outcomes for people with a specific type of advanced colorectal cancer (pMMR/MSS) before surgery. About 166 participants will be randomly assigned to receive either the …

This early-phase study tests a new drug called OKN4395, alone or with an immunotherapy (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses and see if the drug can shrink tumors. About 166…

This study tests an experimental drug called BMS-986523, either alone or with other cancer medicines, in people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change (KRAS). The main goals are to see if the drug is safe and to fin…

This early-phase study tests a new drug called TH9619 in people with advanced solid tumors, including colorectal, head and neck, lung, and stomach cancers. The main goal is to find a safe dose and check for side effects. About 43 adults who have already tried at least one standar…

This study is for people with stage I or low-risk stage II colorectal cancer who have a positive ctDNA blood test one month after surgery, indicating a higher risk of the cancer coming back. The trial will compare different chemotherapy plans to see which one clears the ctDNA fro…

This study tests a combination of two cancer drugs (fruquintinib and FOLFIRI) as a second treatment option for people with metastatic colorectal cancer whose first treatment stopped working. About 60 adults will receive the drug combo to see if it can slow cancer growth and how s…

This study tests a new drug called JYP0015 in adults with advanced solid tumors that have a specific genetic change called RAS mutation. The goal is to see if the drug is safe and can shrink tumors. About 210 people with pancreatic, lung, or colorectal cancer will take part.

This study is testing a new treatment that delivers radiation directly to cancer cells in people with advanced solid tumors that cannot be removed by surgery. The treatment uses a special molecule to find and attach to cancer cells, then delivers a radioactive payload to destroy …

This study tests a new drug, tegavivint, in people with metastatic colorectal cancer that has worsened after at least two prior treatments. The trial aims to find a safe dose and see if the drug works alone or with standard therapies. About 126 adults aged 18 and older will take …

This study tests an experimental drug called RMC-6236 in about 754 adults with advanced solid tumors that have specific RAS gene mutations, including certain lung, colorectal, and pancreatic cancers. The main goals are to check the drug's safety and find the right dose. Participa…

This study tests a new drug, ABT-301, combined with two existing cancer drugs (tislelizumab and bevacizumab) in people with advanced colorectal cancer that hasn't responded to at least two prior treatments. The goal is to find the safest dose and see if the combination shrinks tu…

This study is looking for better ways to detect colorectal cancer early by analyzing bacteria in stool samples. Researchers will collect samples from 30,000 people aged 40-74 in the Lisbon area and compare their gut microbiome with colonoscopy results. The goal is to find bacteri…

This study is looking for 400 adults in Portugal, aged 40 to 74, who have recently been diagnosed with colorectal cancer but have not yet started treatment. Researchers want to see if the types and genes of bacteria in a person's stool can help detect cancer earlier, especially i…

This study is collecting blood samples from 1,300 people in the United States to improve a DNA-based blood test that can detect colorectal cancer and advanced adenomas (precancerous polyps). Participants include people newly diagnosed with colorectal cancer or advanced adenomas, …

This study is testing a new blood test called Delta-HLD to see how well it can detect colorectal cancer in average-risk people aged 45 to 75. About 3,200 participants will give a blood sample before their scheduled screening colonoscopy. The test results will be compared to the c…

This study is testing whether a home stool test (FIT) can accurately detect if bowel cancer has returned after surgery. About 1,000 patients who are due for a routine colonoscopy will also provide a FIT sample. If the test works well, some patients might be able to skip the colon…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. The study will involve 172 participants…

This study is gathering detailed information from 625 people with colorectal or pancreatic cancer that has spread to the liver, as well as from healthy volunteers. Researchers will analyze tumor and blood samples to understand how the immune system interacts with these cancers. T…

This study looks at whether people hospitalized with a bloodstream infection caused by certain gut bacteria might have undiagnosed colon cancer or precancerous growths. About 100 adults will swallow a tiny camera in a capsule (colon capsule endoscopy) a few weeks after leaving th…

This study is looking at whether proteins in urine can help doctors predict how well pre-surgery treatment works for people with locally advanced colorectal cancer. Researchers will collect urine samples from 400 patients before and after treatment and use advanced technology to …

This study looks at whether the type of anesthesia used during colorectal cancer surgery affects how much muscle patients lose afterward. Researchers will measure muscle mass and strength in 40 adults using ultrasound, grip tests, and body composition scans. The goal is to find w…