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New t cell engager takes on tough colorectal cancer

NCT ID NCT07321106

Recruiting now Disease control Sponsor: Cartography Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This early-phase trial tests a new drug called CBI-1214 in 80 people with advanced colorectal cancer that has not responded to standard treatments. CBI-1214 is designed to connect the body's own immune T cells to cancer cells, helping the immune system attack the tumor. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CBI-1214 (a T cell engager that links immune cells to cancer cells)
What this could lead to
If it works, this could point toward a new treatment option for advanced colorectal cancer that is hard to treat with current therapies.
What could go wrong
This is a very early, first-in-human trial with only 80 participants. The drug may not shrink tumors or could cause significant side effects. Many early-stage cancer drugs do not advance to later trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm colorectal cancer colorectal carcinoma colorectal neoplasm malignant colon neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED COLORECTAL CANCER COLON CANCER COLORECTAL (COLON OR RECTAL) CANCER COLORECTAL CANCER COLORECTAL CANCER (CRC) CRC METASTATIC COLON CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • City of Hope Duarte

    RECRUITING

    Duarte, California, 91010, United States

  • Emory Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Mayo Clinic Arizona

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Florida

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • NEXT Oncology

    RECRUITING

    San Antonio, Texas, 78229, United States

  • NEXT Oncology

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • START Midwest

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

    Contact Email: •••••@•••••

  • UCLA

    RECRUITING

    Los Angeles, California, 90095, United States

  • UCSF

    RECRUITING

    San Francisco, California, 94158, United States

  • Valkyrie Clinical Trials

    RECRUITING

    Los Angeles, California, 91402, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.