ADVANCED COLORECTAL CANCER

This study is testing whether an experimental drug called RBS2418, which aims to boost the immune system's ability to fight cancer, can help control advanced colorectal cancer. It will involve about 150 adults whose cancer has continued to progress despite trying all standard tre…

This study is testing whether giving two chemotherapy drugs together works better than standard treatments for advanced colorectal cancer. Researchers will enroll 583 adults with newly diagnosed, advanced disease who haven't had previous treatment. The main goal is to see if this…

This is a first-in-human study to test the safety and find the right dose of a new drug called BGB-53038. It targets a specific genetic change (KRAS mutation) found in many advanced solid tumors like lung, colorectal, and pancreatic cancers. The drug will be tested alone and in c…

This study is testing whether a combination of three drugs—avutometinib, defactinib, and cetuximab—can help control advanced colorectal cancer that has spread, cannot be surgically removed, and has stopped responding to standard anti-EGFR therapy. It will enroll about 33 adults t…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This study is testing a new combination of three drugs and a short course of radiation given before surgery for locally advanced rectal cancer. The goal is to shrink the tumor as much as possible, ideally to the point where no cancer cells are found after surgery. The study will …