Mini tumors in a dish could pick the right drug for stubborn cancers

NCT ID NCT05267912

Recruiting now Knowledge-focused Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether growing a patient's tumor cells in the lab (as 3D 'organoids') can help doctors pick the best drug for advanced cancers that have stopped responding to standard treatments. About 152 adults with colorectal or pancreatic cancer will have a biopsy to create these organoids, which are then exposed to a panel of drugs to see which ones work. The goal is to see if this personalized approach is feasible and can improve how long patients live without their cancer growing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tumor organoid-based chemogram (lab test on biopsy sample)
What this could lead to: If successful, this could help doctors choose more effective drugs for patients with advanced cancers that have stopped responding to standard treatments.
What could go wrong: This is an early feasibility study, not a treatment trial. The organoid test may not always predict real patient responses, and results may not lead to better outcomes for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED, PRETREATED SOLID TUMORS

Contacts and locations

Locations

CHU de Poitiers
NOT_YET_RECRUITING

Poitiers, France, 86000, France
Centre Eugène Marquis
RECRUITING

Rennes, France, 35000, France
Centre Léon Bérard
ACTIVE_NOT_RECRUITING

Lyon, France, 69008, France
Centre Oscar Lambret
RECRUITING

Lille, France, 59000, France
Gustave Roussy
RECRUITING

Villejuif, 94805, France
HIA Bégin
RECRUITING

Saint-Mandé, France, 94160, France
Hôpital Pitié-Salpêtrière
RECRUITING

Paris, France, 75013, France
Hôpital Saint Louis
RECRUITING

Paris, France, 75010, France
Hôpital St Antoine
RECRUITING

Paris, France, 75571, France
Institut Bergonié
RECRUITING

Bordeaux, France, 33000, France
Institut Godinot
RECRUITING

Reims, France, 51726, France

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