New hope for Hard-to-Treat colorectal cancer: drug combo enters Mid-Stage trial
NCT ID NCT06589830
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial is testing whether a new drug called TL938, taken as a pill, combined with the targeted therapy trastuzumab (given by IV), can shrink tumors in people with HER2-positive colorectal cancer that has spread or come back. The study will enroll 80 adults who have already tried several standard treatments. Researchers aim to find the best dose and measure how many patients respond to the combination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TL938 capsules and trastuzumab (injection)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with HER2-positive colorectal cancer that has spread and not responded to standard therapies.
- What could go wrong
- This is an early Phase 2 trial with only 80 participants, so results may not apply to all patients. The drug combination may cause side effects or fail to shrink tumors in many participants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cancer Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, China
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