COLORECTAL CANCER METASTATIC

This early-phase trial tests a personalized vaccine called COLONYVAQ-CRC, designed using AI and quantum physics, for patients with stage III colorectal cancer that has been surgically removed. The vaccine is given alongside standard chemotherapy and an immunotherapy drug (nivolum…

This Canadian study tests a modified version of early post-operative chemotherapy given directly into the abdomen after surgery for peritoneal cancer from colorectal or appendix tumors. The standard treatment takes five days, but this new approach shortens it to two days using a …

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these treatments change the immune environment inside the liver tum…

This Phase 2 trial is testing whether a new drug called TL938, taken as a pill, combined with the targeted therapy trastuzumab (given by IV), can shrink tumors in people with HER2-positive colorectal cancer that has spread or come back. The study will enroll 80 adults who have al…

This study tests a technique called in vivo lung perfusion (IVLP), where chemotherapy is delivered directly into one lung during surgery to remove lung tumors. The goal is to kill any remaining cancer cells while reducing side effects on the rest of the body. About 10 adults with…

This study tests whether adding a new drug called isunakinra to the immunotherapy pembrolizumab can help treat advanced colorectal cancer that has not responded to other treatments. The trial will enroll 20 people with a specific type of tumor (MSS, TMB-H, KRAS-mutated). Research…

This early-phase trial is testing whether a drug called Nelitolimod, given directly into the liver through a special catheter, can safely boost the immune system in 10 people with colorectal cancer that has spread to the liver. Participants will receive the drug three times befor…

This study tests a new treatment made from donated cord blood cells that are engineered to recognize and attack colorectal cancer cells. It is for people with advanced or metastatic colorectal cancer that has not responded to standard treatments. The trial will check safety and e…

This study looks at different ways to perform a liver transplant in people whose colorectal cancer has spread to the liver and cannot be removed by surgery. Researchers will compare living versus deceased donor transplants, whole versus split organs, and one-stage versus two-stag…

This study tests a pump that delivers chemotherapy directly to the liver for people with colorectal cancer or bile duct cancer that has spread to the liver. The goal is to see if the pump is safe and if patients can get their pump refilled at a local clinic instead of always trav…

This early-stage trial is testing a new treatment called CNA3103 for people with metastatic colorectal cancer that has spread and not responded well to standard treatments. CNA3103 is made from a patient's own immune cells, which are modified in a lab to better recognize and atta…

This study tests a new form of chemotherapy (liposomal irinotecan) combined with standard drugs for people with advanced colorectal cancer that has not responded to first treatment. About 100 adults aged 18-75 will receive this combination to see if it shrinks tumors and delays c…

This phase 2 trial is testing the drug regorafenib as a second-line treatment for people with advanced colorectal cancer that has a specific mutation in the RAS gene. The study aims to see if a personalized, less intensive treatment approach can help control the cancer and improv…

This phase 2 trial tests whether adding valproic acid (a drug used for epilepsy) to a repeat course of anti-EGFR therapy (irinotecan and panitumumab) can improve outcomes for people with a specific type of metastatic colorectal cancer (RAS/BRAF wild-type). The study will enroll 1…

This study is testing a new drug called ABT-301 combined with two other drugs (tislelizumab and bevacizumab) in people with advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if the combination is safe and can shrink tumors. Abo…

This study tests a two-step approach for people with liver metastases from triple-negative breast cancer, melanoma, or colorectal cancer. First, doctors use heat or cold to destroy some liver tumors, which may release cancer signals that train the immune system. Then, patients re…

This Phase 3 trial is testing whether a combination of two targeted drugs, tunlametinib and vemurafenib, can help people with a specific genetic mutation (BRAF V600E) in metastatic colorectal cancer. About 165 participants will be randomly assigned to receive either the drug comb…

This early-phase study tests a small implantable device placed directly into liver tumors from colorectal cancer. The device releases tiny amounts of several chemotherapy and immunotherapy drugs to see how the tumor responds. After a few days, the device is removed along with the…

This study is creating a large database of 2000 people whose cancer has spread to the liver. Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and improve future care. No new treatments are being tested; the goal is…

This study will follow 600 people with a specific type of advanced colorectal cancer (MSI-high) who are being treated with the immunotherapy drug pembrolizumab. The goal is to understand why about 20-30% of patients do not respond to this treatment. By analyzing tumor samples and…