New hope for Hard-to-Treat colorectal cancer: targeted drug shows promise
NCT ID NCT07213570
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial is testing the drug regorafenib as a second-line treatment for people with advanced colorectal cancer that has a specific mutation in the RAS gene. The study aims to see if a personalized, less intensive treatment approach can help control the cancer and improve quality of life. About 60 participants will receive either regorafenib or standard second-line therapy, and researchers will track how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Regorafenib
- What this could lead to
- If successful, this could offer a less intensive treatment option for people with a specific type of advanced colorectal cancer, potentially improving quality of life while controlling the disease.
- What could go wrong
- This is a small, early-phase study (phase 2) with only 60 participants, so results may not apply to everyone. The drug can cause side effects like fatigue, hand-foot skin reaction, and liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istituto Nazionale Tumori | "Fondazione Pascale"
RECRUITINGNaples, Italy, Italy
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