Can a vaccine boost immunotherapy against a stubborn cancer?
NCT ID NCT05243862
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This phase II trial is testing whether a cancer vaccine called PolyPEPI1018, when combined with the immunotherapy drug atezolizumab, can help people with a specific type of metastatic colorectal cancer that has not responded to previous treatments. The study enrolls adults with microsatellite-stable (MSS) colorectal cancer who have already tried two or three prior therapies. The goal is to see if the combination is safe, triggers an immune response, and shows signs of shrinking tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PolyPEPI1018 vaccine combined with atezolizumab (Tecentriq)
- What this could lead to
- If this combination works, it could offer a new treatment option for people with a type of colorectal cancer that has not responded to standard therapies.
- What could go wrong
- This is a small, early-stage trial, so the benefits are uncertain. The vaccine may not trigger a strong enough immune response, and the combination could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic
Phoenix, Arizona, 85054, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a liver transplant from a living donor help fight colorectal cancer that spread?
- Experimental drug SHR-A1904 takes on Hard-to-Treat colorectal cancer