National Cancer Institute, Naples

This phase 2 trial is testing whether combining a 12-month course of the hormone therapy Relugolix with precise, image-guided radiation can help men with intermediate-risk prostate cancer recover erectile function. Fifty men will receive the treatment and complete questionnaires …

This phase 2 trial is testing whether adding the common cholesterol drug simvastatin to standard chemotherapy and immunotherapy (nivolumab) can help people with a specific genetic mutation (ARID1A) in advanced stomach or esophageal cancer. About 84 participants will receive eithe…

This phase 2 trial tests whether adding valproic acid and simvastatin to standard chemotherapy can help people with untreated metastatic pancreatic cancer live longer without their disease getting worse. About 240 participants will be randomly assigned to receive either the stand…

This Phase 2 trial is testing whether two drugs, pembrolizumab and lenvatinib, can shrink or control vulvar cancer that cannot be surgically removed. About 80 participants will receive the combination in 21-day cycles. The study will measure tumor response and track side effects.

This phase 2 trial is testing the drug regorafenib as a second-line treatment for people with advanced colorectal cancer that has a specific mutation in the RAS gene. The study aims to see if a personalized, less intensive treatment approach can help control the cancer and improv…

This phase 2 trial tests whether adding valproic acid (a drug used for epilepsy) to a repeat course of anti-EGFR therapy (irinotecan and panitumumab) can improve outcomes for people with a specific type of metastatic colorectal cancer (RAS/BRAF wild-type). The study will enroll 1…

This study looks at how well the drug dostarlimab works and how safe it is for people with a certain type of advanced rectal cancer (dMMR/MSI-H). About 50 adults with stage II or III rectal cancer will receive dostarlimab before any other treatment. Researchers will track tumor s…

This study is testing a new robotic system, called da Vinci SP, for surgery to stage and treat endometrial cancer. The surgery involves removing the uterus, ovaries, and fallopian tubes, and checking nearby lymph nodes. Researchers want to see if this robot is safe and effective …

This early-stage study tests a single dose of a new radioactive tracer called [68Ga]Ga-R54, which attaches to a protein (CXCR4) found on some cancer cells. Ten adults with advanced solid tumors or multiple myeloma will receive the tracer and then have a PET/CT scan to see where i…

This study looks at how the cost of cancer treatment affects people with early-stage breast cancer. Researchers will ask 864 patients to fill out questionnaires about their finances and quality of life over one year. The goal is to understand who struggles with medical bills and …

This study is looking at proteins called selenoproteins in people with triple-negative breast cancer (TNBC), a hard-to-treat type. Researchers will measure these proteins in tumor samples and blood from 300 patients and 100 healthy women. The goal is to see if selenoproteins can …

This study is gathering information from 15,000 cancer patients registered on the ROC platform across multiple centers. The goal is to track how quickly patients move through diagnosis, treatment decisions, and care, and to identify where delays or extra costs occur. No new treat…