National Cancer Institute, Naples

This study is testing if adding a common cholesterol-lowering drug, simvastatin, to standard first-line treatment helps control advanced stomach and esophageal cancer. It will enroll 84 patients who have a specific genetic change (ARID1A mutation) and have not had prior treatment…

This study is testing whether a combination of two existing drugs, pembrolizumab and lenvatinib, can help control advanced vulvar cancer. It will enroll 80 women whose cancer cannot be removed by surgery, has come back, or has spread. The main goals are to see if the treatment sh…

This study is testing whether using an artificial intelligence (AI) system to guide how much fluid patients receive during major cancer surgery leads to more stable blood pressure and better recovery. Researchers will compare the AI-guided approach to standard fluid management in…

This study aims to see if adding a specific cannabis extract to standard pain medication helps reduce the overall burden of symptoms in people with advanced cancer. It will involve 156 adults who are already on strong painkillers and are experiencing significant symptoms like pai…

This study aims to gather information on the safety and effectiveness of a complex surgery for advanced or recurring gynecologic cancers that have spread to major blood vessels. It will look back at past patient records and follow new patients to see how they fare in terms of sur…